Coincidence of genetic loci for plasma cholesterol levels and obesity in a multifactorial mouse model

Craig H Warden, Janis S. Fisler, Mario J. Pace, Karen L. Svenson, Aidons J. Lusis

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

We have examined backcross progeny derived from a cross of Mus spretus with C57BL/6J, that range from 1 to 50% carcass lipid (n = 215), and from 22 to 130 mg/dl plasma total cholesterol (n = 238). Statistical analysis̀ revealed that distal mouse chromosome 7 exhibits significant linkage both to plasma total cholesterol (likelihood of the odds [LOD] 5.8) and to carcass lipid (LOD 3.8). A locus on chromosome 6 also shows significant linkage to plasma total cholesterol (LOD 5.6), but no linkage to carcass lipid. Neither chromosomal region contains any previously mapped genes likely to influence lipoprotein metabolism, indicating that novel genetic factors contributing to plasma lipoprotein levels have been identified.

Original languageEnglish (US)
Pages (from-to)773-779
Number of pages7
JournalJournal of Clinical Investigation
Volume92
Issue number2
StatePublished - Aug 1993

Keywords

  • Cholesterol
  • Genetics
  • Linkage (genetics)
  • Lipoproteins
  • Obesity

ASJC Scopus subject areas

  • Medicine(all)

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    Warden, C. H., Fisler, J. S., Pace, M. J., Svenson, K. L., & Lusis, A. J. (1993). Coincidence of genetic loci for plasma cholesterol levels and obesity in a multifactorial mouse model. Journal of Clinical Investigation, 92(2), 773-779.