Coherence gating and adaptive optics in the eye

Donald T. Miller, Junle Qu, Ravi Jonnal, Karen Thorn

Research output: Contribution to journalConference articlepeer-review

76 Scopus citations


An en face coherence gated camera equipped with adaptive optics (AO) has been constructed for imaging single cells in the living human retina. The high axial resolution of coherence gating combined with the high transverse resolution of AO provides a powerful imaging tool whose image quality can surpass either methodology performing alone. The AO system relies on a 37-actuator Xinetics mirror and a Shack-Hartmann wavefront sensor that executes up to 22 corrections per second. The coherence gate is realized with a free-space Michelson interferometer that employs a scientific-grade 12-bit CCD array for recording 2-D retinal interferogram's. Images were collected of microstructures the size of single cells in the in vivo retina. Early results suggest that a coherence gated adaptive optics camera should substantially improve our ability to detect single cells in the retina over the current state-of-the-art AO retina cameras, including conventional flood illuminated and confocal scanning laser ophthalmoscopes. To our knowledge, this is the first effort to combine coherence gating and adaptive optics.

Original languageEnglish (US)
Pages (from-to)65-72
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - Dec 5 2003
Externally publishedYes
EventPROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII - San Jose, CA, United States
Duration: Jan 27 2003Jan 29 2003


  • Adaptive optics
  • Coherence gating
  • Cone photoreceptors
  • Eye
  • Optical coherence tomography
  • Retina

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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