Abstract
An en face coherence gated camera equipped with adaptive optics (AO) has been constructed for imaging single cells in the living human retina. The high axial resolution of coherence gating combined with the high transverse resolution of AO provides a powerful imaging tool whose image quality can surpass either methodology performing alone. The AO system relies on a 37-actuator Xinetics mirror and a Shack-Hartmann wavefront sensor that executes up to 22 corrections per second. The coherence gate is realized with a free-space Michelson interferometer that employs a scientific-grade 12-bit CCD array for recording 2-D retinal interferogram's. Images were collected of microstructures the size of single cells in the in vivo retina. Early results suggest that a coherence gated adaptive optics camera should substantially improve our ability to detect single cells in the retina over the current state-of-the-art AO retina cameras, including conventional flood illuminated and confocal scanning laser ophthalmoscopes. To our knowledge, this is the first effort to combine coherence gating and adaptive optics.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 65-72 |
| Number of pages | 8 |
| Journal | Proceedings of SPIE - The International Society for Optical Engineering |
| Volume | 4956 |
| DOIs | |
| State | Published - Dec 5 2003 |
| Externally published | Yes |
| Event | PROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII - San Jose, CA, United States Duration: Jan 27 2003 → Jan 29 2003 |
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Keywords
- Adaptive optics
- Coherence gating
- Cone photoreceptors
- Eye
- Optical coherence tomography
- Retina
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Computer Science Applications
- Applied Mathematics
- Electrical and Electronic Engineering
Cite this
Coherence gating and adaptive optics in the eye. / Miller, Donald T.; Qu, Junle; Jonnal, Ravi; Thorn, Karen.
In: Proceedings of SPIE - The International Society for Optical Engineering, Vol. 4956, 05.12.2003, p. 65-72.Research output: Contribution to journal › Conference article
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TY - JOUR
T1 - Coherence gating and adaptive optics in the eye
AU - Miller, Donald T.
AU - Qu, Junle
AU - Jonnal, Ravi
AU - Thorn, Karen
PY - 2003/12/5
Y1 - 2003/12/5
N2 - An en face coherence gated camera equipped with adaptive optics (AO) has been constructed for imaging single cells in the living human retina. The high axial resolution of coherence gating combined with the high transverse resolution of AO provides a powerful imaging tool whose image quality can surpass either methodology performing alone. The AO system relies on a 37-actuator Xinetics mirror and a Shack-Hartmann wavefront sensor that executes up to 22 corrections per second. The coherence gate is realized with a free-space Michelson interferometer that employs a scientific-grade 12-bit CCD array for recording 2-D retinal interferogram's. Images were collected of microstructures the size of single cells in the in vivo retina. Early results suggest that a coherence gated adaptive optics camera should substantially improve our ability to detect single cells in the retina over the current state-of-the-art AO retina cameras, including conventional flood illuminated and confocal scanning laser ophthalmoscopes. To our knowledge, this is the first effort to combine coherence gating and adaptive optics.
AB - An en face coherence gated camera equipped with adaptive optics (AO) has been constructed for imaging single cells in the living human retina. The high axial resolution of coherence gating combined with the high transverse resolution of AO provides a powerful imaging tool whose image quality can surpass either methodology performing alone. The AO system relies on a 37-actuator Xinetics mirror and a Shack-Hartmann wavefront sensor that executes up to 22 corrections per second. The coherence gate is realized with a free-space Michelson interferometer that employs a scientific-grade 12-bit CCD array for recording 2-D retinal interferogram's. Images were collected of microstructures the size of single cells in the in vivo retina. Early results suggest that a coherence gated adaptive optics camera should substantially improve our ability to detect single cells in the retina over the current state-of-the-art AO retina cameras, including conventional flood illuminated and confocal scanning laser ophthalmoscopes. To our knowledge, this is the first effort to combine coherence gating and adaptive optics.
KW - Adaptive optics
KW - Coherence gating
KW - Cone photoreceptors
KW - Eye
KW - Optical coherence tomography
KW - Retina
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U2 - 10.1117/12.477633
DO - 10.1117/12.477633
M3 - Conference article
VL - 4956
SP - 65
EP - 72
JO - Proceedings of SPIE - The International Society for Optical Engineering
JF - Proceedings of SPIE - The International Society for Optical Engineering
SN - 0277-786X
ER -