Cognitive profiles of boys with the fragile X syndrome

M. B. Kemper, Randi J Hagerman, D. Altshul-Stark

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Testing 20 boys with the fragile X (or Martin-Bell) syndrome with the Kaufman Assessment Battery for Children (K-ABC) showed a consistent pattern of strengths and weaknesses that may be useful in predicting a fragile X positive result from cytogenetic testing. This K-ABC pattern included 1) Sequential Scale score less than the Simultaneous Scale score; 2) Mental Processing Composite less than the Achievement Scale score; 3) Spatial Memory subtest score less than the Matrix Analogies subtest score; and 4) Arithmetic subtest score less than the mean of the Achievement subtest scores. A comparison group of 20 boys did not demonstrate such a pattern. Testing with the K-ABC should be considered for boys who present as learning disabled, hyperactive with attention problems, or mildly retarded. Boys with three or four of the four features of the K-ABC fragile X pattern should be considered for medical evaluation and cytogenetic testing.

Original languageEnglish (US)
Pages (from-to)191-200
Number of pages10
JournalAmerican Journal of Medical Genetics
Volume30
Issue number1-2
StatePublished - 1988
Externally publishedYes

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Fragile X Syndrome
Cytogenetics
Learning

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Cognitive profiles of boys with the fragile X syndrome. / Kemper, M. B.; Hagerman, Randi J; Altshul-Stark, D.

In: American Journal of Medical Genetics, Vol. 30, No. 1-2, 1988, p. 191-200.

Research output: Contribution to journalArticle

Kemper, MB, Hagerman, RJ & Altshul-Stark, D 1988, 'Cognitive profiles of boys with the fragile X syndrome', American Journal of Medical Genetics, vol. 30, no. 1-2, pp. 191-200.
Kemper, M. B. ; Hagerman, Randi J ; Altshul-Stark, D. / Cognitive profiles of boys with the fragile X syndrome. In: American Journal of Medical Genetics. 1988 ; Vol. 30, No. 1-2. pp. 191-200.
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