Cognitive profiles in dementia Alzheimer disease vs healthy brain aging

David K Johnson, M. Storandt, J. C. Morris, Z. D. Langford, J. E. Galvin

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Objective: To re-examine proposed models of cognitive test performance that concluded separate factor structures were required for people with Alzheimer disease (AD) and older adults without dementia. Methods: Five models of cognitive test performance were compared using multistep confirmatory factor analysis in 115 individuals with autopsy-confirmed AD and 191 research participants without clinical dementia from longitudinal studies at the Washington University AD Research Center. The models were then cross-validated using independent samples of 323 people with clinically diagnosed dementia of the Alzheimer type and 212 cognitively healthy older adults. Results: After controlling for Alzheimer-specific changes in episodic memory, performance on the battery of tests used here was best represented in people both with and without dementia by a single model of one general factor and three specific factors (verbal memory, visuospatial ability, and working memory). Performance by people with dementia was lower on the general factor than it was by those without dementia. Larger variances associated with the specific factors in the group with dementia indicated greater individual differences in the pattern of cognitive deficits in the stage of AD. Conclusions: A hybrid model of general and specific cognitive domains simplifies cognitive research by allowing direct comparison of normal aging and Alzheimer disease performance. The presence of a general factor maximizes detection of the dementia, whereas the specific factors reveal the heterogeneity of dementia's associated cognitive deficits.

Original languageEnglish (US)
Pages (from-to)1783-1789
Number of pages7
JournalNeurology
Volume71
Issue number22
DOIs
StatePublished - Nov 25 2008
Externally publishedYes

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Dementia
Alzheimer Disease
Brain
Research
Aptitude
Episodic Memory
Short-Term Memory
Individuality
Statistical Factor Analysis
Longitudinal Studies
Autopsy

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Cognitive profiles in dementia Alzheimer disease vs healthy brain aging. / Johnson, David K; Storandt, M.; Morris, J. C.; Langford, Z. D.; Galvin, J. E.

In: Neurology, Vol. 71, No. 22, 25.11.2008, p. 1783-1789.

Research output: Contribution to journalArticle

Johnson, DK, Storandt, M, Morris, JC, Langford, ZD & Galvin, JE 2008, 'Cognitive profiles in dementia Alzheimer disease vs healthy brain aging', Neurology, vol. 71, no. 22, pp. 1783-1789. https://doi.org/10.1212/01.wnl.0000335972.35970.70
Johnson, David K ; Storandt, M. ; Morris, J. C. ; Langford, Z. D. ; Galvin, J. E. / Cognitive profiles in dementia Alzheimer disease vs healthy brain aging. In: Neurology. 2008 ; Vol. 71, No. 22. pp. 1783-1789.
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