Cognitive event-related potentials: Biomarkers of synaptic dysfunction across the stages of Alzheimer's disease

John M Olichney; Jin Chen Yang; Jason Taylor; Marta Kutas

doi:10.3233/978-1-60750-793-2-421

Cognitive event-related potentials: Biomarkers of synaptic dysfunction across the stages of Alzheimer's disease

John M Olichney, Jin Chen Yang, Jason Taylor, Marta Kutas

Neurology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Cognitive event-related brain potential (ERP) studies of decision-making and attention, language, and memory impairments in Alzheimer's disease (AD) and mild cognitive impairment (MCI) are reviewed. Circumscribed lesions of the medial temporal lobe (MTL), as may be the case in individuals with amnestic MCI, generally produce altered plasticity of the late positive P600 component, with relative sparing of earlier sensory ERP components. However, as the neuropathology of AD extends to neocortical association areas, abnormalities of the P300 and N400 (and perhaps even P50) become more common. Critically, ERP studies of individuals at risk for AD may reveal neurophysiological changes prior to clinical deficits, which could advance the early detection and diagnosis of presymptomatic AD.

Original language	English (US)
Pages (from-to)	421-434
Number of pages	14
Journal	Advances in Alzheimer's Disease
Volume	2
DOIs	https://doi.org/10.3233/978-1-60750-793-2-421
State	Published - 2011

Keywords

Alzheimer's disease (AD)
EEG
event-related potentials (ERP)
Late Positive Component (LPC)
mild cognitive impairment (MCI)
N400
P300
P600
preclinical AD
synaptic dysfunction

ASJC Scopus subject areas

Clinical Neurology

Access to Document

10.3233/978-1-60750-793-2-421

Fingerprint Dive into the research topics of 'Cognitive event-related potentials: Biomarkers of synaptic dysfunction across the stages of Alzheimer's disease'. Together they form a unique fingerprint.

Cite this

@article{bbda79978cb140dcaeca48021be11579,

title = "Cognitive event-related potentials: Biomarkers of synaptic dysfunction across the stages of Alzheimer's disease",

abstract = "Cognitive event-related brain potential (ERP) studies of decision-making and attention, language, and memory impairments in Alzheimer's disease (AD) and mild cognitive impairment (MCI) are reviewed. Circumscribed lesions of the medial temporal lobe (MTL), as may be the case in individuals with amnestic MCI, generally produce altered plasticity of the late positive P600 component, with relative sparing of earlier sensory ERP components. However, as the neuropathology of AD extends to neocortical association areas, abnormalities of the P300 and N400 (and perhaps even P50) become more common. Critically, ERP studies of individuals at risk for AD may reveal neurophysiological changes prior to clinical deficits, which could advance the early detection and diagnosis of presymptomatic AD.",

keywords = "Alzheimer's disease (AD), EEG, event-related potentials (ERP), Late Positive Component (LPC), mild cognitive impairment (MCI), N400, P300, P600, preclinical AD, synaptic dysfunction",

author = "Olichney, {John M} and Yang, {Jin Chen} and Jason Taylor and Marta Kutas",

year = "2011",

doi = "10.3233/978-1-60750-793-2-421",

language = "English (US)",

volume = "2",

pages = "421--434",

journal = "Advances in Alzheimer's Disease",

issn = "2210-5727",

publisher = "IOS Press",

}

TY - JOUR

T1 - Cognitive event-related potentials

T2 - Biomarkers of synaptic dysfunction across the stages of Alzheimer's disease

AU - Olichney, John M

AU - Yang, Jin Chen

AU - Taylor, Jason

AU - Kutas, Marta

PY - 2011

Y1 - 2011

N2 - Cognitive event-related brain potential (ERP) studies of decision-making and attention, language, and memory impairments in Alzheimer's disease (AD) and mild cognitive impairment (MCI) are reviewed. Circumscribed lesions of the medial temporal lobe (MTL), as may be the case in individuals with amnestic MCI, generally produce altered plasticity of the late positive P600 component, with relative sparing of earlier sensory ERP components. However, as the neuropathology of AD extends to neocortical association areas, abnormalities of the P300 and N400 (and perhaps even P50) become more common. Critically, ERP studies of individuals at risk for AD may reveal neurophysiological changes prior to clinical deficits, which could advance the early detection and diagnosis of presymptomatic AD.

AB - Cognitive event-related brain potential (ERP) studies of decision-making and attention, language, and memory impairments in Alzheimer's disease (AD) and mild cognitive impairment (MCI) are reviewed. Circumscribed lesions of the medial temporal lobe (MTL), as may be the case in individuals with amnestic MCI, generally produce altered plasticity of the late positive P600 component, with relative sparing of earlier sensory ERP components. However, as the neuropathology of AD extends to neocortical association areas, abnormalities of the P300 and N400 (and perhaps even P50) become more common. Critically, ERP studies of individuals at risk for AD may reveal neurophysiological changes prior to clinical deficits, which could advance the early detection and diagnosis of presymptomatic AD.

KW - Alzheimer's disease (AD)

KW - EEG

KW - event-related potentials (ERP)

KW - Late Positive Component (LPC)

KW - mild cognitive impairment (MCI)

KW - N400

KW - P300

KW - P600

KW - preclinical AD

KW - synaptic dysfunction

UR - http://www.scopus.com/inward/record.url?scp=84865405708&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865405708&partnerID=8YFLogxK

U2 - 10.3233/978-1-60750-793-2-421

DO - 10.3233/978-1-60750-793-2-421

M3 - Article

AN - SCOPUS:84865405708

VL - 2

SP - 421

EP - 434

JO - Advances in Alzheimer's Disease

JF - Advances in Alzheimer's Disease

SN - 2210-5727

ER -