Abstract
Cognitive event-related brain potential (ERP) studies of decision-making and attention, language, and memory impairments in Alzheimer's disease (AD) and mild cognitive impairment (MCI) are reviewed. Circumscribed lesions of the medial temporal lobe (MTL), as may be the case in individuals with amnestic MCI, generally produce altered plasticity of the late positive P600 component, with relative sparing of earlier sensory ERP components. However, as the neuropathology of AD extends to neocortical association areas, abnormalities of the P300 and N400 (and perhaps even P50) become more common. Critically, ERP studies of individuals at risk for AD may reveal neurophysiological changes prior to clinical deficits, which could advance the early detection and diagnosis of presymptomatic AD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 421-434 |
| Number of pages | 14 |
| Journal | Advances in Alzheimer's Disease |
| Volume | 2 |
| DOIs | |
| State | Published - 2011 |
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Keywords
- Alzheimer's disease (AD)
- EEG
- event-related potentials (ERP)
- Late Positive Component (LPC)
- mild cognitive impairment (MCI)
- N400
- P300
- P600
- preclinical AD
- synaptic dysfunction
ASJC Scopus subject areas
- Clinical Neurology
Cite this
Cognitive event-related potentials : Biomarkers of synaptic dysfunction across the stages of Alzheimer's disease. / Olichney, John M; Yang, Jin Chen; Taylor, Jason; Kutas, Marta.
In: Advances in Alzheimer's Disease, Vol. 2, 2011, p. 421-434.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cognitive event-related potentials
T2 - Biomarkers of synaptic dysfunction across the stages of Alzheimer's disease
AU - Olichney, John M
AU - Yang, Jin Chen
AU - Taylor, Jason
AU - Kutas, Marta
PY - 2011
Y1 - 2011
N2 - Cognitive event-related brain potential (ERP) studies of decision-making and attention, language, and memory impairments in Alzheimer's disease (AD) and mild cognitive impairment (MCI) are reviewed. Circumscribed lesions of the medial temporal lobe (MTL), as may be the case in individuals with amnestic MCI, generally produce altered plasticity of the late positive P600 component, with relative sparing of earlier sensory ERP components. However, as the neuropathology of AD extends to neocortical association areas, abnormalities of the P300 and N400 (and perhaps even P50) become more common. Critically, ERP studies of individuals at risk for AD may reveal neurophysiological changes prior to clinical deficits, which could advance the early detection and diagnosis of presymptomatic AD.
AB - Cognitive event-related brain potential (ERP) studies of decision-making and attention, language, and memory impairments in Alzheimer's disease (AD) and mild cognitive impairment (MCI) are reviewed. Circumscribed lesions of the medial temporal lobe (MTL), as may be the case in individuals with amnestic MCI, generally produce altered plasticity of the late positive P600 component, with relative sparing of earlier sensory ERP components. However, as the neuropathology of AD extends to neocortical association areas, abnormalities of the P300 and N400 (and perhaps even P50) become more common. Critically, ERP studies of individuals at risk for AD may reveal neurophysiological changes prior to clinical deficits, which could advance the early detection and diagnosis of presymptomatic AD.
KW - Alzheimer's disease (AD)
KW - EEG
KW - event-related potentials (ERP)
KW - Late Positive Component (LPC)
KW - mild cognitive impairment (MCI)
KW - N400
KW - P300
KW - P600
KW - preclinical AD
KW - synaptic dysfunction
UR - http://www.scopus.com/inward/record.url?scp=84865405708&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865405708&partnerID=8YFLogxK
U2 - 10.3233/978-1-60750-793-2-421
DO - 10.3233/978-1-60750-793-2-421
M3 - Article
VL - 2
SP - 421
EP - 434
JO - Advances in Alzheimer's Disease
JF - Advances in Alzheimer's Disease
SN - 2210-5727
ER -