Cognitive event-related potentials: Biomarkers of synaptic dysfunction across the stages of Alzheimers Disease

John M Olichney, Jin Chen Yang, Jason Taylor, Marta Kutas

Research output: Contribution to journalArticle

48 Scopus citations


Cognitive event-related brain potential (ERP) studies of decision-making and attention, language, and memory impairments in Alzheimers disease (AD) and mild cognitive impairment (MCI) are reviewed. Circumscribed lesions of the medial temporal lobe (MTL), as may be the case in individuals with amnestic MCI, generally produce altered plasticity of the late positive P600 component, with relative sparing of earlier sensory ERP components. However, as the neuropathology of AD extends to neocortical association areas, abnormalities of the P300 and N400 (and perhaps even P50) become more common. Critically, ERP studies of individuals at risk for AD may reveal neurophysiological changes prior to clinical deficits, which could advance the early detection and diagnosis of "presymptomatic AD".

Original languageEnglish (US)
Pages (from-to)215-228
Number of pages14
JournalJournal of Alzheimer's Disease
Issue numberSUPPL. 3
StatePublished - 2011



  • Alzheimers disease (AD)
  • EEG
  • event-related potentials (ERP)
  • Late Positive Component (LPC)
  • mild cognitive impairment (MCI)
  • N400
  • P300
  • P600
  • preclinical AD
  • synaptic dysfunction

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

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