Cognitive dysfunction in psychiatric disorders: Characteristics, causes and the quest for improved therapy

Mark J. Millan, Yves Agid, Martin Brüne, Edward T. Bullmore, Cameron S Carter, Nicola S. Clayton, Richard Connor, Sabrina Davis, Bill Deakin, Robert J. Derubeis, Bruno Dubois, Mark A. Geyer, Guy M. Goodwin, Philip Gorwood, Thérèse M. Jay, Marian Joëls, Isabelle M. Mansuy, Andreas Meyer-Lindenberg, Declan Murphy, Edmund RollsBernd Saletu, Michael Spedding, John Sweeney, Miles Whittington, Larry J. Young

Research output: Contribution to journalArticle

570 Scopus citations

Abstract

Studies of psychiatric disorders have traditionally focused on emotional symptoms such as depression, anxiety and hallucinations. However, poorly controlled cognitive deficits are equally prominent and severely compromise quality of life, including social and professional integration. Consequently, intensive efforts are being made to characterize the cellular and cerebral circuits underpinning cognitive function, define the nature and causes of cognitive impairment in psychiatric disorders and identify more effective treatments. Successful development will depend on rigorous validation in animal models as well as in patients, including measures of real-world cognitive functioning. This article critically discusses these issues, highlighting the challenges and opportunities for improving cognition in individuals suffering from psychiatric disorders.

Original languageEnglish (US)
Pages (from-to)141-168
Number of pages28
JournalNature Reviews Drug Discovery
Volume11
Issue number2
DOIs
StatePublished - Feb 2012

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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    Millan, M. J., Agid, Y., Brüne, M., Bullmore, E. T., Carter, C. S., Clayton, N. S., Connor, R., Davis, S., Deakin, B., Derubeis, R. J., Dubois, B., Geyer, M. A., Goodwin, G. M., Gorwood, P., Jay, T. M., Joëls, M., Mansuy, I. M., Meyer-Lindenberg, A., Murphy, D., ... Young, L. J. (2012). Cognitive dysfunction in psychiatric disorders: Characteristics, causes and the quest for improved therapy. Nature Reviews Drug Discovery, 11(2), 141-168. https://doi.org/10.1038/nrd3628