Abstract
Many colorectal cancers (CRCs) develop in genetically susceptible individuals most of whom are not carriers of germ line mismatch repair or APC gene mutations and much of the heritable risk of CRC appears to be attributable to the co-inheritance of multiple low-risk variants. The accumulated experience to date in identifying this class of susceptibility allele has highlighted the need to conduct statistically and methodologically rigorous studies and the need for the multi-centre collaboration. This has been the motivation for establishing the COGENT (COlorectal cancer GENeTics) consortium which now includes over 20 research groups in Europe, Australia, the Americas, China and Japan actively working on CRC genetics. Here, we review the rationale for identifying low-penetrance variants for CRC and the current and future challenges for COGENT.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 143-151 |
| Number of pages | 9 |
| Journal | Mutagenesis |
| Volume | 27 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1 2012 |
| Externally published | Yes |
ASJC Scopus subject areas
- Genetics
- Toxicology
- Genetics(clinical)
- Health, Toxicology and Mutagenesis
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COGENT (COlorectal cancer GENeTics) revisited. / Tomlinson, I.; Dunlop, M.; Campbell, H.; Zanke, B.; Gallinger, S.; Hudson, T.; Koessler, T.; Pharoah, P. D.; Niittymäki, I.; Tuupanen, S.; Aaltonen, L. A.; Hemminki, K.; Lindblom, A.; Försti, A.; Sieber, O.; Lipton, L.; van Wezel, T.; Morreau, H.; Wijnen, J. T.; Devilee, P.; Matsuda, K.; Nakamura, Y.; Castellví-Bel, S.; Ruiz-Ponte, C.; Castells, A.; Carracedo, A.; Ho, J. W.C.; Sham, P.; Vodicka, P.; Brenner, H.; Hampe, J.; Schafmayer, C.; Tepel, J.; Schreiber, S.; Völzke, H.; Lerch, M. M.; Schmidt, C. A.; Buch, S.; Moreno, V.; Villanueva, C. M.; Peterlongo, P.; Radice, P.; Li, L.; Echeverry, M. M.; Bohorquez, M.; Velez, A.; Carvajal-Carmona, L.; Scott, R.; Penegar, S.; Broderick, P.; Tenesa, A.; Houlston, R. S.; Maher, Eamonn; Evans, Gareth; Walker, Lisa; Halliday, Dorothy; Lucassen, Anneke; Paterson, Joan; Hodgson, Shirley; Homfray, Tessa; Side, Lucy; Izatt, Louise; Donaldson, Alan; Tomkins, Susan; Morrison, Patrick; Brewer, Carole; Henderson, Alex; Davidson, Rosemarie; Murday, Victoria; Cook, Jaqueline; Haites, Neva; Bishop, Timothy; Sheridan, Eamonn; Green, Andrew; Marks, Christopher; Carpenter, Sue; Broughton, Mary; Lynn Greenhalge, Surrey; Suri, Mohnish; Diego Morillas, Juan; Muñoz, Raquel; Manzano, Marisa; Colina, Francisco; Díaz, Jose; Ibarrola, Carolina; López, Guadalupe; Castells, Antoni; Piñol, Virgínia; Castellví-Bel, Sergi; Balaguer, Francesc; Gonzalo, Victoria; Ocaña, Teresa; Giráldez, María Dolores; Pellisé, Maria; Serradesanferm, Anna; Moreira, Leticia; Cuatrecasas, Miriam; Piqué, Josep M.; Lanas, Ángel; Alcedo, Javier; Ortego, Javier; Cubiella, Joaquin; Díez, M. Soledad; Salgado, Mercedes; Sánchez, Eloy; Andreu, Montserrat; Abuli, Anna; Bessa, Xavier; Iglesias, Mar; Seoane, Agustín; Bory, Felipe; Navarro, Gemma; Bellosillo Josep Mª Dedeu, Beatriz; Álvarez, Cristina; Bujanda, Luis; Cosme, Ángel; Gil, Inés; Larzabal, Mikel; Placer, Carlos; del Mar Ramírez, María; Hijona, Elisabeth; Enríquez-Navascués y Jose L, Jose M.; Payá, Artemio; Jover, Rodrigo; Alenda, Cristina; Sempere, Laura; Acame, Nuria; Rojas, Estefanía; Rigau, Joaquim; Serrano, Ángel; Giménez, Anna; Saló, Joan; Batiste-Alentorn, Eduard; Autonell, Josefina; María García, Ana; Carballo, Fernando; Bienvenido, Antonio; Sanz, Eduardo; González, Fernando; Sánchez, Jaime; Latorre, Mercedes; Medina, Enrique; Cuquerella, Jaime; Canelles, Pilar; Martorell, Miguel; García, José Ángel; Quiles, Francisco; Clofent, Juan; Seoane, Jaime; Tardío, Antoni; Sanchez, Eugenia; de Castro, Luisa; Tardío, Antoni; Clofent, Juan; Llor, Xavier; Xicola, Rosa M.; Piñol, Marta; Rosinach, Mercè; Roca, Anna; Pons, Elisenda; Hernández, José M.; Fernández-Bañares, Fernando; Viver, Josep M.; Salas, Antonio; Espinós, Jorge; M. Reñé, Josep; Piñol, Carmen; Buenestado, Juan; Quintero, Enrique; Nicolás, David; Parra, Adolfo; Argüello, Lidia; Pons, Vicente; Pertejo, Virginia; Gonzalez, Dolors; Roman, Eva; Ramon, Teresa; Poca, Maria; Concepción, M. Mar; Martin, Marta; Martinez, Daniel; Carracedo, Angel; Ruiz-Ponte, Clara; Fernández-Rozadilla, Ceres; Riestra, Sabino; Fernández, Javier; Carreño, Luis; Oquiñena, Susana; Bolado, Federico.
In: Mutagenesis, Vol. 27, No. 2, 01.03.2012, p. 143-151.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - COGENT (COlorectal cancer GENeTics) revisited
AU - Tomlinson, I.
AU - Dunlop, M.
AU - Campbell, H.
AU - Zanke, B.
AU - Gallinger, S.
AU - Hudson, T.
AU - Koessler, T.
AU - Pharoah, P. D.
AU - Niittymäki, I.
AU - Tuupanen, S.
AU - Aaltonen, L. A.
AU - Hemminki, K.
AU - Lindblom, A.
AU - Försti, A.
AU - Sieber, O.
AU - Lipton, L.
AU - van Wezel, T.
AU - Morreau, H.
AU - Wijnen, J. T.
AU - Devilee, P.
AU - Matsuda, K.
AU - Nakamura, Y.
AU - Castellví-Bel, S.
AU - Ruiz-Ponte, C.
AU - Castells, A.
AU - Carracedo, A.
AU - Ho, J. W.C.
AU - Sham, P.
AU - Vodicka, P.
AU - Brenner, H.
AU - Hampe, J.
AU - Schafmayer, C.
AU - Tepel, J.
AU - Schreiber, S.
AU - Völzke, H.
AU - Lerch, M. M.
AU - Schmidt, C. A.
AU - Buch, S.
AU - Moreno, V.
AU - Villanueva, C. M.
AU - Peterlongo, P.
AU - Radice, P.
AU - Li, L.
AU - Echeverry, M. M.
AU - Bohorquez, M.
AU - Velez, A.
AU - Carvajal-Carmona, L.
AU - Scott, R.
AU - Penegar, S.
AU - Broderick, P.
AU - Tenesa, A.
AU - Houlston, R. S.
AU - Maher, Eamonn
AU - Evans, Gareth
AU - Walker, Lisa
AU - Halliday, Dorothy
AU - Lucassen, Anneke
AU - Paterson, Joan
AU - Hodgson, Shirley
AU - Homfray, Tessa
AU - Side, Lucy
AU - Izatt, Louise
AU - Donaldson, Alan
AU - Tomkins, Susan
AU - Morrison, Patrick
AU - Brewer, Carole
AU - Henderson, Alex
AU - Davidson, Rosemarie
AU - Murday, Victoria
AU - Cook, Jaqueline
AU - Haites, Neva
AU - Bishop, Timothy
AU - Sheridan, Eamonn
AU - Green, Andrew
AU - Marks, Christopher
AU - Carpenter, Sue
AU - Broughton, Mary
AU - Lynn Greenhalge, Surrey
AU - Suri, Mohnish
AU - Diego Morillas, Juan
AU - Muñoz, Raquel
AU - Manzano, Marisa
AU - Colina, Francisco
AU - Díaz, Jose
AU - Ibarrola, Carolina
AU - López, Guadalupe
AU - Castells, Antoni
AU - Piñol, Virgínia
AU - Castellví-Bel, Sergi
AU - Balaguer, Francesc
AU - Gonzalo, Victoria
AU - Ocaña, Teresa
AU - Giráldez, María Dolores
AU - Pellisé, Maria
AU - Serradesanferm, Anna
AU - Moreira, Leticia
AU - Cuatrecasas, Miriam
AU - Piqué, Josep M.
AU - Lanas, Ángel
AU - Alcedo, Javier
AU - Ortego, Javier
AU - Cubiella, Joaquin
AU - Díez, M. Soledad
AU - Salgado, Mercedes
AU - Sánchez, Eloy
AU - Andreu, Montserrat
AU - Abuli, Anna
AU - Bessa, Xavier
AU - Iglesias, Mar
AU - Seoane, Agustín
AU - Bory, Felipe
AU - Navarro, Gemma
AU - Bellosillo Josep Mª Dedeu, Beatriz
AU - Álvarez, Cristina
AU - Bujanda, Luis
AU - Cosme, Ángel
AU - Gil, Inés
AU - Larzabal, Mikel
AU - Placer, Carlos
AU - del Mar Ramírez, María
AU - Hijona, Elisabeth
AU - Enríquez-Navascués y Jose L, Jose M.
AU - Payá, Artemio
AU - Jover, Rodrigo
AU - Alenda, Cristina
AU - Sempere, Laura
AU - Acame, Nuria
AU - Rojas, Estefanía
AU - Rigau, Joaquim
AU - Serrano, Ángel
AU - Giménez, Anna
AU - Saló, Joan
AU - Batiste-Alentorn, Eduard
AU - Autonell, Josefina
AU - María García, Ana
AU - Carballo, Fernando
AU - Bienvenido, Antonio
AU - Sanz, Eduardo
AU - González, Fernando
AU - Sánchez, Jaime
AU - Latorre, Mercedes
AU - Medina, Enrique
AU - Cuquerella, Jaime
AU - Canelles, Pilar
AU - Martorell, Miguel
AU - García, José Ángel
AU - Quiles, Francisco
AU - Clofent, Juan
AU - Seoane, Jaime
AU - Tardío, Antoni
AU - Sanchez, Eugenia
AU - de Castro, Luisa
AU - Tardío, Antoni
AU - Clofent, Juan
AU - Llor, Xavier
AU - Xicola, Rosa M.
AU - Piñol, Marta
AU - Rosinach, Mercè
AU - Roca, Anna
AU - Pons, Elisenda
AU - Hernández, José M.
AU - Fernández-Bañares, Fernando
AU - Viver, Josep M.
AU - Salas, Antonio
AU - Espinós, Jorge
AU - M. Reñé, Josep
AU - Piñol, Carmen
AU - Buenestado, Juan
AU - Quintero, Enrique
AU - Nicolás, David
AU - Parra, Adolfo
AU - Argüello, Lidia
AU - Pons, Vicente
AU - Pertejo, Virginia
AU - Gonzalez, Dolors
AU - Roman, Eva
AU - Ramon, Teresa
AU - Poca, Maria
AU - Concepción, M. Mar
AU - Martin, Marta
AU - Martinez, Daniel
AU - Carracedo, Angel
AU - Ruiz-Ponte, Clara
AU - Fernández-Rozadilla, Ceres
AU - Riestra, Sabino
AU - Fernández, Javier
AU - Carreño, Luis
AU - Oquiñena, Susana
AU - Bolado, Federico
PY - 2012/3/1
Y1 - 2012/3/1
N2 - Many colorectal cancers (CRCs) develop in genetically susceptible individuals most of whom are not carriers of germ line mismatch repair or APC gene mutations and much of the heritable risk of CRC appears to be attributable to the co-inheritance of multiple low-risk variants. The accumulated experience to date in identifying this class of susceptibility allele has highlighted the need to conduct statistically and methodologically rigorous studies and the need for the multi-centre collaboration. This has been the motivation for establishing the COGENT (COlorectal cancer GENeTics) consortium which now includes over 20 research groups in Europe, Australia, the Americas, China and Japan actively working on CRC genetics. Here, we review the rationale for identifying low-penetrance variants for CRC and the current and future challenges for COGENT.
AB - Many colorectal cancers (CRCs) develop in genetically susceptible individuals most of whom are not carriers of germ line mismatch repair or APC gene mutations and much of the heritable risk of CRC appears to be attributable to the co-inheritance of multiple low-risk variants. The accumulated experience to date in identifying this class of susceptibility allele has highlighted the need to conduct statistically and methodologically rigorous studies and the need for the multi-centre collaboration. This has been the motivation for establishing the COGENT (COlorectal cancer GENeTics) consortium which now includes over 20 research groups in Europe, Australia, the Americas, China and Japan actively working on CRC genetics. Here, we review the rationale for identifying low-penetrance variants for CRC and the current and future challenges for COGENT.
UR - http://www.scopus.com/inward/record.url?scp=84856944802&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856944802&partnerID=8YFLogxK
U2 - 10.1093/mutage/ger059
DO - 10.1093/mutage/ger059
M3 - Article
C2 - 22294761
AN - SCOPUS:84856944802
VL - 27
SP - 143
EP - 151
JO - Mutagenesis
JF - Mutagenesis
SN - 0267-8357
IS - 2
ER -