COGENT (COlorectal cancer GENeTics) revisited

I. Tomlinson, M. Dunlop, H. Campbell, B. Zanke, S. Gallinger, T. Hudson, T. Koessler, P. D. Pharoah, I. Niittymäki, S. Tuupanen, L. A. Aaltonen, K. Hemminki, A. Lindblom, A. Försti, O. Sieber, L. Lipton, T. van Wezel, H. Morreau, J. T. Wijnen, P. DevileeK. Matsuda, Y. Nakamura, S. Castellví-Bel, C. Ruiz-Ponte, A. Castells, A. Carracedo, J. W.C. Ho, P. Sham, P. Vodicka, H. Brenner, J. Hampe, C. Schafmayer, J. Tepel, S. Schreiber, H. Völzke, M. M. Lerch, C. A. Schmidt, S. Buch, V. Moreno, C. M. Villanueva, P. Peterlongo, P. Radice, L. Li, M. M. Echeverry, M. Bohorquez, A. Velez, L. Carvajal-Carmona, R. Scott, S. Penegar, P. Broderick, A. Tenesa, R. S. Houlston, Eamonn Maher, Gareth Evans, Lisa Walker, Dorothy Halliday, Anneke Lucassen, Joan Paterson, Shirley Hodgson, Tessa Homfray, Lucy Side, Louise Izatt, Alan Donaldson, Susan Tomkins, Patrick Morrison, Carole Brewer, Alex Henderson, Rosemarie Davidson, Victoria Murday, Jaqueline Cook, Neva Haites, Timothy Bishop, Eamonn Sheridan, Andrew Green, Christopher Marks, Sue Carpenter, Mary Broughton, Surrey Lynn Greenhalge, Mohnish Suri, Juan Diego Morillas, Raquel Muñoz, Marisa Manzano, Francisco Colina, Jose Díaz, Carolina Ibarrola, Guadalupe López, Antoni Castells, Virgínia Piñol, Sergi Castellví-Bel, Francesc Balaguer, Victoria Gonzalo, Teresa Ocaña, María Dolores Giráldez, Maria Pellisé, Anna Serradesanferm, Leticia Moreira, Miriam Cuatrecasas, Josep M. Piqué, Ángel Lanas, Javier Alcedo, Javier Ortego, Joaquin Cubiella, M. Soledad Díez, Mercedes Salgado, Eloy Sánchez, Montserrat Andreu, Anna Abuli, Xavier Bessa, Mar Iglesias, Agustín Seoane, Felipe Bory, Gemma Navarro, Beatriz Bellosillo Josep Mª Dedeu, Cristina Álvarez, Luis Bujanda, Ángel Cosme, Inés Gil, Mikel Larzabal, Carlos Placer, María del Mar Ramírez, Elisabeth Hijona, Jose M. Enríquez-Navascués y Jose L, Artemio Payá, Rodrigo Jover, Cristina Alenda, Laura Sempere, Nuria Acame, Estefanía Rojas, Joaquim Rigau, Ángel Serrano, Anna Giménez, Joan Saló, Eduard Batiste-Alentorn, Josefina Autonell, Ana María García, Fernando Carballo, Antonio Bienvenido, Eduardo Sanz, Fernando González, Jaime Sánchez, Mercedes Latorre, Enrique Medina, Jaime Cuquerella, Pilar Canelles, Miguel Martorell, José Ángel García, Francisco Quiles, Juan Clofent, Jaime Seoane, Antoni Tardío, Eugenia Sanchez, Luisa de Castro, Antoni Tardío, Juan Clofent, Xavier Llor, Rosa M. Xicola, Marta Piñol, Mercè Rosinach, Anna Roca, Elisenda Pons, José M. Hernández, Fernando Fernández-Bañares, Josep M. Viver, Antonio Salas, Jorge Espinós, Josep M. Reñé, Carmen Piñol, Juan Buenestado, Enrique Quintero, David Nicolás, Adolfo Parra, Lidia Argüello, Vicente Pons, Virginia Pertejo, Dolors Gonzalez, Eva Roman, Teresa Ramon, Maria Poca, M. Mar Concepción, Marta Martin, Daniel Martinez, Angel Carracedo, Clara Ruiz-Ponte, Ceres Fernández-Rozadilla, Sabino Riestra, Javier Fernández, Luis Carreño, Susana Oquiñena, Federico Bolado

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Many colorectal cancers (CRCs) develop in genetically susceptible individuals most of whom are not carriers of germ line mismatch repair or APC gene mutations and much of the heritable risk of CRC appears to be attributable to the co-inheritance of multiple low-risk variants. The accumulated experience to date in identifying this class of susceptibility allele has highlighted the need to conduct statistically and methodologically rigorous studies and the need for the multi-centre collaboration. This has been the motivation for establishing the COGENT (COlorectal cancer GENeTics) consortium which now includes over 20 research groups in Europe, Australia, the Americas, China and Japan actively working on CRC genetics. Here, we review the rationale for identifying low-penetrance variants for CRC and the current and future challenges for COGENT.

Original languageEnglish (US)
Pages (from-to)143-151
Number of pages9
JournalMutagenesis
Volume27
Issue number2
DOIs
StatePublished - Mar 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Toxicology
  • Genetics(clinical)
  • Health, Toxicology and Mutagenesis

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