Abstract
It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.
Original language | English (US) |
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Pages (from-to) | 447-454 |
Number of pages | 8 |
Journal | British Journal of Cancer |
Volume | 102 |
Issue number | 2 |
DOIs | |
State | Published - Jan 2010 |
Externally published | Yes |
Keywords
- Association
- Colorectal cancer
- Polymorphism
ASJC Scopus subject areas
- Cancer Research
- Oncology