COGENT (COlorectal cancer GENeTics): An international consortium to study the role of polymorphic variation on the risk of colorectal cancer

I. P M Tomlinson; M. Dunlop; H. Campbell; B. Zanke; S. Gallinger; T. Hudson; T. Koessler; P. D. Pharoah; I. Niittymäkix; S. Tuupanenx; L. A. Aaltonen; K. Hemminki; A. Lindblom; A. Försti; O. Sieber; L. Lipton; T. Van Wezel; H. Morreau; J. T. Wijnen; P. Devilee; K. Matsuda; Y. Nakamura; S. Castellví-Bel; C. Ruiz-Ponte; A. Castells; A. Carracedo; J. W C Ho; P. Sham; R. M W Hofstra; P. Vodicka; H. Brenner; J. Hampe; C. Schafmayer; J. Tepel; S. Schreiber; H. Völzke; M. M. Lerch; C. A. Schmidt; S. Buch; V. Moreno; C. M. Villanueva; P. Peterlongo; P. Radice; M. M. Echeverry; A. Velez; Luis Carvajal-Carmona; R. Scott; S. Penegar; P. Broderick; A. Tenesa; R. S. Houlston

doi:10.1038/sj.bjc.6605338

COGENT (COlorectal cancer GENeTics): An international consortium to study the role of polymorphic variation on the risk of colorectal cancer

I. P M Tomlinson, M. Dunlop, H. Campbell, B. Zanke, S. Gallinger, T. Hudson, T. Koessler, P. D. Pharoah, I. Niittymäkix, S. Tuupanenx, L. A. Aaltonen, K. Hemminki, A. Lindblom, A. Försti, O. Sieber, L. Lipton, T. Van Wezel, H. Morreau, J. T. Wijnen, P. DevileeK. Matsuda, Y. Nakamura, S. Castellví-Bel, C. Ruiz-Ponte, A. Castells, A. Carracedo, J. W C Ho, P. Sham, R. M W Hofstra, P. Vodicka, H. Brenner, J. Hampe, C. Schafmayer, J. Tepel, S. Schreiber, H. Völzke, M. M. Lerch, C. A. Schmidt, S. Buch, V. Moreno, C. M. Villanueva, P. Peterlongo, P. Radice, M. M. Echeverry, A. Velez, Luis Carvajal-Carmona, R. Scott, S. Penegar, P. Broderick, A. Tenesa, R. S. Houlston

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.

Original language	English (US)
Pages (from-to)	447-454
Number of pages	8
Journal	British Journal of Cancer
Volume	102
Issue number	2
DOIs	https://doi.org/10.1038/sj.bjc.6605338
State	Published - Jan 2010
Externally published	Yes

Keywords

Association
Colorectal cancer
Polymorphism

ASJC Scopus subject areas

Cancer Research
Oncology

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Tomlinson, I. P. M., Dunlop, M., Campbell, H., Zanke, B., Gallinger, S., Hudson, T., Koessler, T., Pharoah, P. D., Niittymäkix, I., Tuupanenx, S., Aaltonen, L. A., Hemminki, K., Lindblom, A., Försti, A., Sieber, O., Lipton, L., Van Wezel, T., Morreau, H., Wijnen, J. T., ... Houlston, R. S. (2010). COGENT (COlorectal cancer GENeTics): An international consortium to study the role of polymorphic variation on the risk of colorectal cancer. British Journal of Cancer, 102(2), 447-454. https://doi.org/10.1038/sj.bjc.6605338

COGENT (COlorectal cancer GENeTics) : An international consortium to study the role of polymorphic variation on the risk of colorectal cancer. / Tomlinson, I. P M; Dunlop, M.; Campbell, H.; Zanke, B.; Gallinger, S.; Hudson, T.; Koessler, T.; Pharoah, P. D.; Niittymäkix, I.; Tuupanenx, S.; Aaltonen, L. A.; Hemminki, K.; Lindblom, A.; Försti, A.; Sieber, O.; Lipton, L.; Van Wezel, T.; Morreau, H.; Wijnen, J. T.; Devilee, P.; Matsuda, K.; Nakamura, Y.; Castellví-Bel, S.; Ruiz-Ponte, C.; Castells, A.; Carracedo, A.; Ho, J. W C; Sham, P.; Hofstra, R. M W; Vodicka, P.; Brenner, H.; Hampe, J.; Schafmayer, C.; Tepel, J.; Schreiber, S.; Völzke, H.; Lerch, M. M.; Schmidt, C. A.; Buch, S.; Moreno, V.; Villanueva, C. M.; Peterlongo, P.; Radice, P.; Echeverry, M. M.; Velez, A.; Carvajal-Carmona, Luis; Scott, R.; Penegar, S.; Broderick, P.; Tenesa, A.; Houlston, R. S.

In: British Journal of Cancer, Vol. 102, No. 2, 01.2010, p. 447-454.

Research output: Contribution to journal › Article › peer-review

Tomlinson, IPM, Dunlop, M, Campbell, H, Zanke, B, Gallinger, S, Hudson, T, Koessler, T, Pharoah, PD, Niittymäkix, I, Tuupanenx, S, Aaltonen, LA, Hemminki, K, Lindblom, A, Försti, A, Sieber, O, Lipton, L, Van Wezel, T, Morreau, H, Wijnen, JT, Devilee, P, Matsuda, K, Nakamura, Y, Castellví-Bel, S, Ruiz-Ponte, C, Castells, A, Carracedo, A, Ho, JWC, Sham, P, Hofstra, RMW, Vodicka, P, Brenner, H, Hampe, J, Schafmayer, C, Tepel, J, Schreiber, S, Völzke, H, Lerch, MM, Schmidt, CA, Buch, S, Moreno, V, Villanueva, CM, Peterlongo, P, Radice, P, Echeverry, MM, Velez, A, Carvajal-Carmona, L, Scott, R, Penegar, S, Broderick, P, Tenesa, A & Houlston, RS 2010, 'COGENT (COlorectal cancer GENeTics): An international consortium to study the role of polymorphic variation on the risk of colorectal cancer', British Journal of Cancer, vol. 102, no. 2, pp. 447-454. https://doi.org/10.1038/sj.bjc.6605338

Tomlinson, I. P M ; Dunlop, M. ; Campbell, H. ; Zanke, B. ; Gallinger, S. ; Hudson, T. ; Koessler, T. ; Pharoah, P. D. ; Niittymäkix, I. ; Tuupanenx, S. ; Aaltonen, L. A. ; Hemminki, K. ; Lindblom, A. ; Försti, A. ; Sieber, O. ; Lipton, L. ; Van Wezel, T. ; Morreau, H. ; Wijnen, J. T. ; Devilee, P. ; Matsuda, K. ; Nakamura, Y. ; Castellví-Bel, S. ; Ruiz-Ponte, C. ; Castells, A. ; Carracedo, A. ; Ho, J. W C ; Sham, P. ; Hofstra, R. M W ; Vodicka, P. ; Brenner, H. ; Hampe, J. ; Schafmayer, C. ; Tepel, J. ; Schreiber, S. ; Völzke, H. ; Lerch, M. M. ; Schmidt, C. A. ; Buch, S. ; Moreno, V. ; Villanueva, C. M. ; Peterlongo, P. ; Radice, P. ; Echeverry, M. M. ; Velez, A. ; Carvajal-Carmona, Luis ; Scott, R. ; Penegar, S. ; Broderick, P. ; Tenesa, A. ; Houlston, R. S. / COGENT (COlorectal cancer GENeTics) : An international consortium to study the role of polymorphic variation on the risk of colorectal cancer. In: British Journal of Cancer. 2010 ; Vol. 102, No. 2. pp. 447-454.

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title = "COGENT (COlorectal cancer GENeTics): An international consortium to study the role of polymorphic variation on the risk of colorectal cancer",

abstract = "It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.",

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year = "2010",

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doi = "10.1038/sj.bjc.6605338",

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AU - Dunlop, M.

AU - Campbell, H.

AU - Zanke, B.

AU - Gallinger, S.

AU - Hudson, T.

AU - Koessler, T.

AU - Pharoah, P. D.

AU - Niittymäkix, I.

AU - Tuupanenx, S.

AU - Aaltonen, L. A.

AU - Hemminki, K.

AU - Lindblom, A.

AU - Försti, A.

AU - Sieber, O.

AU - Lipton, L.

AU - Van Wezel, T.

AU - Morreau, H.

AU - Wijnen, J. T.

AU - Devilee, P.

AU - Matsuda, K.

AU - Nakamura, Y.

AU - Castellví-Bel, S.

AU - Ruiz-Ponte, C.

AU - Castells, A.

AU - Carracedo, A.

AU - Ho, J. W C

AU - Sham, P.

AU - Hofstra, R. M W

AU - Vodicka, P.

AU - Brenner, H.

AU - Hampe, J.

AU - Schafmayer, C.

AU - Tepel, J.

AU - Schreiber, S.

AU - Völzke, H.

AU - Lerch, M. M.

AU - Schmidt, C. A.

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AU - Moreno, V.

AU - Villanueva, C. M.

AU - Peterlongo, P.

AU - Radice, P.

AU - Echeverry, M. M.

AU - Velez, A.

AU - Carvajal-Carmona, Luis

AU - Scott, R.

AU - Penegar, S.

AU - Broderick, P.

AU - Tenesa, A.

AU - Houlston, R. S.

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AB - It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.

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KW - Colorectal cancer

KW - Polymorphism

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COGENT (COlorectal cancer GENeTics): An international consortium to study the role of polymorphic variation on the risk of colorectal cancer

Abstract

Keywords

ASJC Scopus subject areas

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