Abstract
It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 447-454 |
| Number of pages | 8 |
| Journal | British Journal of Cancer |
| Volume | 102 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 2010 |
| Externally published | Yes |
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Keywords
- Association
- Colorectal cancer
- Polymorphism
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
COGENT (COlorectal cancer GENeTics) : An international consortium to study the role of polymorphic variation on the risk of colorectal cancer. / Tomlinson, I. P M; Dunlop, M.; Campbell, H.; Zanke, B.; Gallinger, S.; Hudson, T.; Koessler, T.; Pharoah, P. D.; Niittymäkix, I.; Tuupanenx, S.; Aaltonen, L. A.; Hemminki, K.; Lindblom, A.; Försti, A.; Sieber, O.; Lipton, L.; Van Wezel, T.; Morreau, H.; Wijnen, J. T.; Devilee, P.; Matsuda, K.; Nakamura, Y.; Castellví-Bel, S.; Ruiz-Ponte, C.; Castells, A.; Carracedo, A.; Ho, J. W C; Sham, P.; Hofstra, R. M W; Vodicka, P.; Brenner, H.; Hampe, J.; Schafmayer, C.; Tepel, J.; Schreiber, S.; Völzke, H.; Lerch, M. M.; Schmidt, C. A.; Buch, S.; Moreno, V.; Villanueva, C. M.; Peterlongo, P.; Radice, P.; Echeverry, M. M.; Velez, A.; Carvajal-Carmona, Luis; Scott, R.; Penegar, S.; Broderick, P.; Tenesa, A.; Houlston, R. S.
In: British Journal of Cancer, Vol. 102, No. 2, 01.2010, p. 447-454.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - COGENT (COlorectal cancer GENeTics)
T2 - An international consortium to study the role of polymorphic variation on the risk of colorectal cancer
AU - Tomlinson, I. P M
AU - Dunlop, M.
AU - Campbell, H.
AU - Zanke, B.
AU - Gallinger, S.
AU - Hudson, T.
AU - Koessler, T.
AU - Pharoah, P. D.
AU - Niittymäkix, I.
AU - Tuupanenx, S.
AU - Aaltonen, L. A.
AU - Hemminki, K.
AU - Lindblom, A.
AU - Försti, A.
AU - Sieber, O.
AU - Lipton, L.
AU - Van Wezel, T.
AU - Morreau, H.
AU - Wijnen, J. T.
AU - Devilee, P.
AU - Matsuda, K.
AU - Nakamura, Y.
AU - Castellví-Bel, S.
AU - Ruiz-Ponte, C.
AU - Castells, A.
AU - Carracedo, A.
AU - Ho, J. W C
AU - Sham, P.
AU - Hofstra, R. M W
AU - Vodicka, P.
AU - Brenner, H.
AU - Hampe, J.
AU - Schafmayer, C.
AU - Tepel, J.
AU - Schreiber, S.
AU - Völzke, H.
AU - Lerch, M. M.
AU - Schmidt, C. A.
AU - Buch, S.
AU - Moreno, V.
AU - Villanueva, C. M.
AU - Peterlongo, P.
AU - Radice, P.
AU - Echeverry, M. M.
AU - Velez, A.
AU - Carvajal-Carmona, Luis
AU - Scott, R.
AU - Penegar, S.
AU - Broderick, P.
AU - Tenesa, A.
AU - Houlston, R. S.
PY - 2010/1
Y1 - 2010/1
N2 - It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.
AB - It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.
KW - Association
KW - Colorectal cancer
KW - Polymorphism
UR - http://www.scopus.com/inward/record.url?scp=75549083862&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75549083862&partnerID=8YFLogxK
U2 - 10.1038/sj.bjc.6605338
DO - 10.1038/sj.bjc.6605338
M3 - Article
C2 - 19920828
AN - SCOPUS:75549083862
VL - 102
SP - 447
EP - 454
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 2
ER -