COGENT (COlorectal cancer GENeTics): An international consortium to study the role of polymorphic variation on the risk of colorectal cancer

I. P M Tomlinson, M. Dunlop, H. Campbell, B. Zanke, S. Gallinger, T. Hudson, T. Koessler, P. D. Pharoah, I. Niittymäkix, S. Tuupanenx, L. A. Aaltonen, K. Hemminki, A. Lindblom, A. Försti, O. Sieber, L. Lipton, T. Van Wezel, H. Morreau, J. T. Wijnen, P. DevileeK. Matsuda, Y. Nakamura, S. Castellví-Bel, C. Ruiz-Ponte, A. Castells, A. Carracedo, J. W C Ho, P. Sham, R. M W Hofstra, P. Vodicka, H. Brenner, J. Hampe, C. Schafmayer, J. Tepel, S. Schreiber, H. Völzke, M. M. Lerch, C. A. Schmidt, S. Buch, V. Moreno, C. M. Villanueva, P. Peterlongo, P. Radice, M. M. Echeverry, A. Velez, Luis Carvajal-Carmona, R. Scott, S. Penegar, P. Broderick, A. Tenesa, R. S. Houlston

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.

Original languageEnglish (US)
Pages (from-to)447-454
Number of pages8
JournalBritish Journal of Cancer
Volume102
Issue number2
DOIs
StatePublished - Jan 2010
Externally publishedYes

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Colorectal Neoplasms
Penetrance
China
Japan
Research

Keywords

  • Association
  • Colorectal cancer
  • Polymorphism

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

COGENT (COlorectal cancer GENeTics) : An international consortium to study the role of polymorphic variation on the risk of colorectal cancer. / Tomlinson, I. P M; Dunlop, M.; Campbell, H.; Zanke, B.; Gallinger, S.; Hudson, T.; Koessler, T.; Pharoah, P. D.; Niittymäkix, I.; Tuupanenx, S.; Aaltonen, L. A.; Hemminki, K.; Lindblom, A.; Försti, A.; Sieber, O.; Lipton, L.; Van Wezel, T.; Morreau, H.; Wijnen, J. T.; Devilee, P.; Matsuda, K.; Nakamura, Y.; Castellví-Bel, S.; Ruiz-Ponte, C.; Castells, A.; Carracedo, A.; Ho, J. W C; Sham, P.; Hofstra, R. M W; Vodicka, P.; Brenner, H.; Hampe, J.; Schafmayer, C.; Tepel, J.; Schreiber, S.; Völzke, H.; Lerch, M. M.; Schmidt, C. A.; Buch, S.; Moreno, V.; Villanueva, C. M.; Peterlongo, P.; Radice, P.; Echeverry, M. M.; Velez, A.; Carvajal-Carmona, Luis; Scott, R.; Penegar, S.; Broderick, P.; Tenesa, A.; Houlston, R. S.

In: British Journal of Cancer, Vol. 102, No. 2, 01.2010, p. 447-454.

Research output: Contribution to journalArticle

Tomlinson, IPM, Dunlop, M, Campbell, H, Zanke, B, Gallinger, S, Hudson, T, Koessler, T, Pharoah, PD, Niittymäkix, I, Tuupanenx, S, Aaltonen, LA, Hemminki, K, Lindblom, A, Försti, A, Sieber, O, Lipton, L, Van Wezel, T, Morreau, H, Wijnen, JT, Devilee, P, Matsuda, K, Nakamura, Y, Castellví-Bel, S, Ruiz-Ponte, C, Castells, A, Carracedo, A, Ho, JWC, Sham, P, Hofstra, RMW, Vodicka, P, Brenner, H, Hampe, J, Schafmayer, C, Tepel, J, Schreiber, S, Völzke, H, Lerch, MM, Schmidt, CA, Buch, S, Moreno, V, Villanueva, CM, Peterlongo, P, Radice, P, Echeverry, MM, Velez, A, Carvajal-Carmona, L, Scott, R, Penegar, S, Broderick, P, Tenesa, A & Houlston, RS 2010, 'COGENT (COlorectal cancer GENeTics): An international consortium to study the role of polymorphic variation on the risk of colorectal cancer', British Journal of Cancer, vol. 102, no. 2, pp. 447-454. https://doi.org/10.1038/sj.bjc.6605338
Tomlinson, I. P M ; Dunlop, M. ; Campbell, H. ; Zanke, B. ; Gallinger, S. ; Hudson, T. ; Koessler, T. ; Pharoah, P. D. ; Niittymäkix, I. ; Tuupanenx, S. ; Aaltonen, L. A. ; Hemminki, K. ; Lindblom, A. ; Försti, A. ; Sieber, O. ; Lipton, L. ; Van Wezel, T. ; Morreau, H. ; Wijnen, J. T. ; Devilee, P. ; Matsuda, K. ; Nakamura, Y. ; Castellví-Bel, S. ; Ruiz-Ponte, C. ; Castells, A. ; Carracedo, A. ; Ho, J. W C ; Sham, P. ; Hofstra, R. M W ; Vodicka, P. ; Brenner, H. ; Hampe, J. ; Schafmayer, C. ; Tepel, J. ; Schreiber, S. ; Völzke, H. ; Lerch, M. M. ; Schmidt, C. A. ; Buch, S. ; Moreno, V. ; Villanueva, C. M. ; Peterlongo, P. ; Radice, P. ; Echeverry, M. M. ; Velez, A. ; Carvajal-Carmona, Luis ; Scott, R. ; Penegar, S. ; Broderick, P. ; Tenesa, A. ; Houlston, R. S. / COGENT (COlorectal cancer GENeTics) : An international consortium to study the role of polymorphic variation on the risk of colorectal cancer. In: British Journal of Cancer. 2010 ; Vol. 102, No. 2. pp. 447-454.
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abstract = "It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.",
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AU - Tomlinson, I. P M

AU - Dunlop, M.

AU - Campbell, H.

AU - Zanke, B.

AU - Gallinger, S.

AU - Hudson, T.

AU - Koessler, T.

AU - Pharoah, P. D.

AU - Niittymäkix, I.

AU - Tuupanenx, S.

AU - Aaltonen, L. A.

AU - Hemminki, K.

AU - Lindblom, A.

AU - Försti, A.

AU - Sieber, O.

AU - Lipton, L.

AU - Van Wezel, T.

AU - Morreau, H.

AU - Wijnen, J. T.

AU - Devilee, P.

AU - Matsuda, K.

AU - Nakamura, Y.

AU - Castellví-Bel, S.

AU - Ruiz-Ponte, C.

AU - Castells, A.

AU - Carracedo, A.

AU - Ho, J. W C

AU - Sham, P.

AU - Hofstra, R. M W

AU - Vodicka, P.

AU - Brenner, H.

AU - Hampe, J.

AU - Schafmayer, C.

AU - Tepel, J.

AU - Schreiber, S.

AU - Völzke, H.

AU - Lerch, M. M.

AU - Schmidt, C. A.

AU - Buch, S.

AU - Moreno, V.

AU - Villanueva, C. M.

AU - Peterlongo, P.

AU - Radice, P.

AU - Echeverry, M. M.

AU - Velez, A.

AU - Carvajal-Carmona, Luis

AU - Scott, R.

AU - Penegar, S.

AU - Broderick, P.

AU - Tenesa, A.

AU - Houlston, R. S.

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KW - Association

KW - Colorectal cancer

KW - Polymorphism

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