Coenzyme Q10 supplementation and heart failure

Uma Singh, Sridevi Devaraj, Ishwarlal Jialal

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the Western world. Oxida-tive stress appears to play a pivotal role in atherosclerosis. Coenzyme Q10 (CoQ10), one of the most important antioxidants, is synthesized de novo by every cell in the body. Its biosynthesis decreases with age and its deficit in tissues is associated with degenerative changes of aging, thus implicating a possible therapeutic role of CoQ10 in human diseases. There is evidence to support the therapeutic value of CoQ10 as an adjunct to standard medical therapy in congestive heart failure. However, much further research is required, especially in the use of state-of-the-art techniques to assess functional outcomes in patients with congestive heart failure.

Original languageEnglish (US)
Pages (from-to)286-293
Number of pages8
JournalNutrition Reviews
Volume65
Issue number6
DOIs
StatePublished - Jun 2007

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coenzyme Q10
heart failure
Heart Failure
therapeutics
Western World
atherosclerosis
human diseases
cardiovascular diseases
morbidity
Atherosclerosis
Cardiovascular Diseases
Therapeutics
Antioxidants
biosynthesis
Morbidity
antioxidants
Mortality
Research

Keywords

  • Cardiovascular disease
  • Coenzyme Q10
  • Heart failure

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Coenzyme Q10 supplementation and heart failure. / Singh, Uma; Devaraj, Sridevi; Jialal, Ishwarlal.

In: Nutrition Reviews, Vol. 65, No. 6, 06.2007, p. 286-293.

Research output: Contribution to journalArticle

Singh, U, Devaraj, S & Jialal, I 2007, 'Coenzyme Q10 supplementation and heart failure', Nutrition Reviews, vol. 65, no. 6, pp. 286-293. https://doi.org/10.1301/nr.2007.jun.286-293
Singh, Uma ; Devaraj, Sridevi ; Jialal, Ishwarlal. / Coenzyme Q10 supplementation and heart failure. In: Nutrition Reviews. 2007 ; Vol. 65, No. 6. pp. 286-293.
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