Cocoa Flavanol-Enriched Snack Bars Containing Phytosterols Effectively Lower Total and Low-Density Lipoprotein Cholesterol Levels

John A. Polagruto, Janice F. Wang-Polagruto, Marlia M. Braun, Luke Lee, Catherine Kwik-Uribe, Carl L Keen

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Background: Dietary intervention studies incorporating phytosterol-enriched margarine spreads have reported significant decreases in total and low-density lipoprotein (LDL) cholesterol in populations with both normal lipid levels and those with hypercholesterolemia. There is emerging support for more diverse and lower-fat phytosterol-enriched matrixes. Controversy exists, however, over whether phytosterol-enriched foods affect serum fat-soluble vitamins. Objective: We investigated whether a flavanol-rich cocoa snack food containing phytosterols would decrease total and LDL cholesterol levels in subjects with hypercholesterolemia and significantly affect serum fat-soluble vitamins and carotenoids. Design: A randomized, double-blind parallel arm study design was used. Subjects were randomized to one of two dietary treatments: a cocoa flavanol-enriched snack bar containing 1.5 g phytosterol (n=32), or a control product containing no phytosterols (n=35). Subjects consumed two servings per day. Results: Consumption of the phytosterol-enriched snack bars but not control bars for 6 weeks was associated with significant reductions in plasma total (4.7%; P<0.01) and LDL cholesterol (6%; P<0.01), and the ratio of total to high-density lipoprotein cholesterol (7.4%; P<0.001). There were no changes in high-density lipoprotein cholesterol, triglycerides, or lipid-adjusted lycopene, β-cryptoxanthin, lutein/zeaxanthin, α-carotene levels, or levels of serum vitamins A or E. A significant reduction in lipid-adjusted serum β-carotene was observed in the phytosterol but not the no-phytosterol-added group (P<0.05). Conclusions: This study supports the use of a novel phytosterol-enriched snack bar to effectively reduce plasma total and LDL cholesterol levels in a population with hypercholesterolemia. The data suggest that the incorporation of this snack food into a balanced diet represents a practical dietary strategy in the management of serum cholesterol levels.

Original languageEnglish (US)
Pages (from-to)1804-1813
Number of pages10
JournalJournal of the American Dietetic Association
Issue number11
StatePublished - Nov 2006
Externally publishedYes

ASJC Scopus subject areas

  • Food Science
  • Medicine(all)


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