Cochlear deoxyglucose uptake: Relationship to stimulus intensity

Paul C. Goodwin, Allen F. Ryan, Frank R Sharp, Nigel K. Woolf, Terence M. Davidson

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The relationship between stimulus intensity and the uptake of 2-deoxyglucose (2-DG) in the cochlea of the gerbil was studied using an autoradiographic technique. In silence, incorporation of labeled 2-DG into stria vascularis and the spiral ligament was significantly higher than for other inner ear structures. With increasing intensity of noise exposure, 2-DG uptake in the spiral ganglion and VIIIth nerve increased dramatically when compared to the lateral wall structures. In contrast, relative 2-DG uptake in the organ of Corti was much less affected by noise exposure. Only at 105 dB SPL, the highest intensity tested, was a modest but statistically significant increase observed in the sensory epithelium. The small change in relative 2-DG uptake observed in the organ of Corti during acoustic stimulation is consistent with Davis' (1965: Quant. Biol. 30, 181-190) battery model of the cochlear transduction process. Alternatively, a larger change may have occurred, but been restricted to a small portion of the epithelium, such as one or both populations of hair cells.

Original languageEnglish (US)
Pages (from-to)215-224
Number of pages10
JournalHearing Research
Volume15
Issue number3
DOIs
StatePublished - 1984

Fingerprint

Cochlea
Deoxyglucose
Organ of Corti
Noise
Epithelium
Spiral Ligament of Cochlea
Stria Vascularis
Spiral Ganglion
Acoustic Stimulation
Gerbillinae
Inner Ear
Population

Keywords

  • autoradiography
  • cochlea
  • deoxyglucose
  • metabolism
  • stimulus intensity

ASJC Scopus subject areas

  • Sensory Systems

Cite this

Cochlear deoxyglucose uptake : Relationship to stimulus intensity. / Goodwin, Paul C.; Ryan, Allen F.; Sharp, Frank R; Woolf, Nigel K.; Davidson, Terence M.

In: Hearing Research, Vol. 15, No. 3, 1984, p. 215-224.

Research output: Contribution to journalArticle

Goodwin, Paul C. ; Ryan, Allen F. ; Sharp, Frank R ; Woolf, Nigel K. ; Davidson, Terence M. / Cochlear deoxyglucose uptake : Relationship to stimulus intensity. In: Hearing Research. 1984 ; Vol. 15, No. 3. pp. 215-224.
@article{4d6dcac130c1420c9a1aa93ad9e87c03,
title = "Cochlear deoxyglucose uptake: Relationship to stimulus intensity",
abstract = "The relationship between stimulus intensity and the uptake of 2-deoxyglucose (2-DG) in the cochlea of the gerbil was studied using an autoradiographic technique. In silence, incorporation of labeled 2-DG into stria vascularis and the spiral ligament was significantly higher than for other inner ear structures. With increasing intensity of noise exposure, 2-DG uptake in the spiral ganglion and VIIIth nerve increased dramatically when compared to the lateral wall structures. In contrast, relative 2-DG uptake in the organ of Corti was much less affected by noise exposure. Only at 105 dB SPL, the highest intensity tested, was a modest but statistically significant increase observed in the sensory epithelium. The small change in relative 2-DG uptake observed in the organ of Corti during acoustic stimulation is consistent with Davis' (1965: Quant. Biol. 30, 181-190) battery model of the cochlear transduction process. Alternatively, a larger change may have occurred, but been restricted to a small portion of the epithelium, such as one or both populations of hair cells.",
keywords = "autoradiography, cochlea, deoxyglucose, metabolism, stimulus intensity",
author = "Goodwin, {Paul C.} and Ryan, {Allen F.} and Sharp, {Frank R} and Woolf, {Nigel K.} and Davidson, {Terence M.}",
year = "1984",
doi = "10.1016/0378-5955(84)90030-3",
language = "English (US)",
volume = "15",
pages = "215--224",
journal = "Hearing Research",
issn = "0378-5955",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Cochlear deoxyglucose uptake

T2 - Relationship to stimulus intensity

AU - Goodwin, Paul C.

AU - Ryan, Allen F.

AU - Sharp, Frank R

AU - Woolf, Nigel K.

AU - Davidson, Terence M.

PY - 1984

Y1 - 1984

N2 - The relationship between stimulus intensity and the uptake of 2-deoxyglucose (2-DG) in the cochlea of the gerbil was studied using an autoradiographic technique. In silence, incorporation of labeled 2-DG into stria vascularis and the spiral ligament was significantly higher than for other inner ear structures. With increasing intensity of noise exposure, 2-DG uptake in the spiral ganglion and VIIIth nerve increased dramatically when compared to the lateral wall structures. In contrast, relative 2-DG uptake in the organ of Corti was much less affected by noise exposure. Only at 105 dB SPL, the highest intensity tested, was a modest but statistically significant increase observed in the sensory epithelium. The small change in relative 2-DG uptake observed in the organ of Corti during acoustic stimulation is consistent with Davis' (1965: Quant. Biol. 30, 181-190) battery model of the cochlear transduction process. Alternatively, a larger change may have occurred, but been restricted to a small portion of the epithelium, such as one or both populations of hair cells.

AB - The relationship between stimulus intensity and the uptake of 2-deoxyglucose (2-DG) in the cochlea of the gerbil was studied using an autoradiographic technique. In silence, incorporation of labeled 2-DG into stria vascularis and the spiral ligament was significantly higher than for other inner ear structures. With increasing intensity of noise exposure, 2-DG uptake in the spiral ganglion and VIIIth nerve increased dramatically when compared to the lateral wall structures. In contrast, relative 2-DG uptake in the organ of Corti was much less affected by noise exposure. Only at 105 dB SPL, the highest intensity tested, was a modest but statistically significant increase observed in the sensory epithelium. The small change in relative 2-DG uptake observed in the organ of Corti during acoustic stimulation is consistent with Davis' (1965: Quant. Biol. 30, 181-190) battery model of the cochlear transduction process. Alternatively, a larger change may have occurred, but been restricted to a small portion of the epithelium, such as one or both populations of hair cells.

KW - autoradiography

KW - cochlea

KW - deoxyglucose

KW - metabolism

KW - stimulus intensity

UR - http://www.scopus.com/inward/record.url?scp=0021171245&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021171245&partnerID=8YFLogxK

U2 - 10.1016/0378-5955(84)90030-3

DO - 10.1016/0378-5955(84)90030-3

M3 - Article

C2 - 6501111

AN - SCOPUS:0021171245

VL - 15

SP - 215

EP - 224

JO - Hearing Research

JF - Hearing Research

SN - 0378-5955

IS - 3

ER -