Cocaine-induced respiratory depression in urethane-anesthetized rats: A possible mechanism of cocaine-induced death

Chui Chung Tseng, Robert W. Derlet, Larry G. Stark, Timothy E Albertson

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Urethane-anesthetized rats were used to study the mechanism of cocaine-induced death. Continuous recording of the changes in five physiological parameters, including respiratory rate (RR), electroencephalogram (EEG), blood pressure (BP), electrocardiogram (ECG), and body temperature (BT), were conducted after intraperitoneal (IP) administration of a single dose of cocaine HCl (70 mg/kg). In the control group (normothermic with core body temperature 37.7±0.1°C spontaneously breathing), the death rate was 88% (15/17), and the average time to respiratory arrest was 12.99±1.40 min (mean±SEM). The first set experiments investigated the contribution of hypothermia to cocaine-induced death. The hypothermic group (core body temperature 33.9±0.3°C and spontaneously breathing) had a death rate of 81.5% (22/27), and an average time to respiratory arrest of 16.70±1.24 min, which was significantly (p<0.05) prolonged. A substantial decrease in respiratory rate was seen in normothermic group, while all the other measured parameters remained relatively stable until respiratory arrest. Sequential arterial blood gas data in this group showed a decrease in PaO2 from 116.0±5.7 mmHg to 57.7±4.6 mmHg, and increase in PaCO2 from 27.7±2.2 mmHg to 42.7±3.0 mmHg, and a decrease in pH from 7.467±0.039 to 7.357±0.003. To confirm that respiratory depression was an important mechanism of cocaine-induced death in this model, ten normothermic rats underwent mechanical ventilation, and all survived cocaine exposure. This study points to the important role of respiratory depression as a cause of cocaine-induced death.

Original languageEnglish (US)
Pages (from-to)625-633
Number of pages9
JournalPharmacology, Biochemistry and Behavior
Volume39
Issue number3
DOIs
StatePublished - 1991

Fingerprint

Urethane
Cocaine
Respiratory Insufficiency
Rats
Body Temperature
Respiratory Rate
Respiration
Hypothermia
Mortality
Blood pressure
Electroencephalography
Electrocardiography
Artificial Respiration
Temperature
Blood
Gases
Blood Pressure
Control Groups
Experiments

Keywords

  • Cocaine
  • Hypothermia
  • Mechanism of death
  • Rat
  • Respiratory depression
  • Seizures
  • Urethane

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Cocaine-induced respiratory depression in urethane-anesthetized rats : A possible mechanism of cocaine-induced death. / Tseng, Chui Chung; Derlet, Robert W.; Stark, Larry G.; Albertson, Timothy E.

In: Pharmacology, Biochemistry and Behavior, Vol. 39, No. 3, 1991, p. 625-633.

Research output: Contribution to journalArticle

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abstract = "Urethane-anesthetized rats were used to study the mechanism of cocaine-induced death. Continuous recording of the changes in five physiological parameters, including respiratory rate (RR), electroencephalogram (EEG), blood pressure (BP), electrocardiogram (ECG), and body temperature (BT), were conducted after intraperitoneal (IP) administration of a single dose of cocaine HCl (70 mg/kg). In the control group (normothermic with core body temperature 37.7±0.1°C spontaneously breathing), the death rate was 88{\%} (15/17), and the average time to respiratory arrest was 12.99±1.40 min (mean±SEM). The first set experiments investigated the contribution of hypothermia to cocaine-induced death. The hypothermic group (core body temperature 33.9±0.3°C and spontaneously breathing) had a death rate of 81.5{\%} (22/27), and an average time to respiratory arrest of 16.70±1.24 min, which was significantly (p<0.05) prolonged. A substantial decrease in respiratory rate was seen in normothermic group, while all the other measured parameters remained relatively stable until respiratory arrest. Sequential arterial blood gas data in this group showed a decrease in PaO2 from 116.0±5.7 mmHg to 57.7±4.6 mmHg, and increase in PaCO2 from 27.7±2.2 mmHg to 42.7±3.0 mmHg, and a decrease in pH from 7.467±0.039 to 7.357±0.003. To confirm that respiratory depression was an important mechanism of cocaine-induced death in this model, ten normothermic rats underwent mechanical ventilation, and all survived cocaine exposure. This study points to the important role of respiratory depression as a cause of cocaine-induced death.",
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