Abstract
Inorganic complexes are versatile platforms for the development of potent and selective pharmaceutical agents. Cobalt possesses a diverse array of properties that can be manipulated to yield promising drug candidates. Investigations into the mechanism of cobalt therapeutic agents can provide valuable insight into the physicochemical properties that can be harnessed for drug development. This review presents examples of bioactive cobalt complexes with special attention to their mechanisms of action. Specifically, cobalt complexes that elicit biological effects through protein inhibition, modification of drug activity, and bioreductive activation are discussed. Insights gained from these examples reveal features of cobalt that can be rationally tuned to produce therapeutics with high specificity and improved efficacy for the biomolecule or pathway of interest.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 189-196 |
| Number of pages | 8 |
| Journal | Current Opinion in Chemical Biology |
| Volume | 17 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 1 2013 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
Cite this
Cobalt derivatives as promising therapeutic agents. / Heffern, Marie; Yamamoto, Natsuho; Holbrook, Robert J.; Eckermann, Amanda L.; Meade, Thomas J.
In: Current Opinion in Chemical Biology, Vol. 17, No. 2, 01.04.2013, p. 189-196.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Cobalt derivatives as promising therapeutic agents
AU - Heffern, Marie
AU - Yamamoto, Natsuho
AU - Holbrook, Robert J.
AU - Eckermann, Amanda L.
AU - Meade, Thomas J.
PY - 2013/4/1
Y1 - 2013/4/1
N2 - Inorganic complexes are versatile platforms for the development of potent and selective pharmaceutical agents. Cobalt possesses a diverse array of properties that can be manipulated to yield promising drug candidates. Investigations into the mechanism of cobalt therapeutic agents can provide valuable insight into the physicochemical properties that can be harnessed for drug development. This review presents examples of bioactive cobalt complexes with special attention to their mechanisms of action. Specifically, cobalt complexes that elicit biological effects through protein inhibition, modification of drug activity, and bioreductive activation are discussed. Insights gained from these examples reveal features of cobalt that can be rationally tuned to produce therapeutics with high specificity and improved efficacy for the biomolecule or pathway of interest.
AB - Inorganic complexes are versatile platforms for the development of potent and selective pharmaceutical agents. Cobalt possesses a diverse array of properties that can be manipulated to yield promising drug candidates. Investigations into the mechanism of cobalt therapeutic agents can provide valuable insight into the physicochemical properties that can be harnessed for drug development. This review presents examples of bioactive cobalt complexes with special attention to their mechanisms of action. Specifically, cobalt complexes that elicit biological effects through protein inhibition, modification of drug activity, and bioreductive activation are discussed. Insights gained from these examples reveal features of cobalt that can be rationally tuned to produce therapeutics with high specificity and improved efficacy for the biomolecule or pathway of interest.
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UR - http://www.scopus.com/inward/citedby.url?scp=84876743813&partnerID=8YFLogxK
U2 - 10.1016/j.cbpa.2012.11.019
DO - 10.1016/j.cbpa.2012.11.019
M3 - Review article
C2 - 23270779
AN - SCOPUS:84876743813
VL - 17
SP - 189
EP - 196
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
SN - 1367-5931
IS - 2
ER -