Cobalt derivatives as promising therapeutic agents

Marie Heffern, Natsuho Yamamoto, Robert J. Holbrook, Amanda L. Eckermann, Thomas J. Meade

Research output: Contribution to journalReview article

70 Scopus citations

Abstract

Inorganic complexes are versatile platforms for the development of potent and selective pharmaceutical agents. Cobalt possesses a diverse array of properties that can be manipulated to yield promising drug candidates. Investigations into the mechanism of cobalt therapeutic agents can provide valuable insight into the physicochemical properties that can be harnessed for drug development. This review presents examples of bioactive cobalt complexes with special attention to their mechanisms of action. Specifically, cobalt complexes that elicit biological effects through protein inhibition, modification of drug activity, and bioreductive activation are discussed. Insights gained from these examples reveal features of cobalt that can be rationally tuned to produce therapeutics with high specificity and improved efficacy for the biomolecule or pathway of interest.

Original languageEnglish (US)
Pages (from-to)189-196
Number of pages8
JournalCurrent Opinion in Chemical Biology
Volume17
Issue number2
DOIs
StatePublished - Apr 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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    Heffern, M., Yamamoto, N., Holbrook, R. J., Eckermann, A. L., & Meade, T. J. (2013). Cobalt derivatives as promising therapeutic agents. Current Opinion in Chemical Biology, 17(2), 189-196. https://doi.org/10.1016/j.cbpa.2012.11.019