Coagulation, inflammation, and responses to injury

E. Pottmeyer, M. J. Vassar, James W Holcroft

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Coagulation and acute inflammation follow all types of tissue trauma. When activated locally at the site of an injury, these processes curtail hemorrhage, clear debris from the injured areas, ward off invasion by infecting organisms, and initiate wound healing. When activated in tissues remote from the initial injury, however, they can precipitate post-traumatic organ failure, such as that seen in the lungs and liver after major injuries; overly robust responses to the initial injury can exhaust the coagulative and inflammatory reserve of the massively injured patient and increase risk for bleeding and infection. Thus, although coagulation and inflammation are essential for survival after injury, a too vigorous response remote from the injury can threaten survival. This article describes how coagulation and inflammation develop in the injured patient, and describes some of the clinical consequences, both beneficial and detrimental, of these processes.

Original languageEnglish (US)
Pages (from-to)683-703
Number of pages21
JournalCritical Care Clinics
Issue number4
StatePublished - 1986

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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