Abstract
Although almost two decades of study point to a central role for aberrant ErbB2 activation in breast cancer, many cellular and biochemical mechanisms underlying ErbB2-induced tumor initiation and progression remain to be resolved. A study by Guo et al. published recently in Cell indicates that the signaling function of β4 integrin actively contributes to the initiation, growth, and invasion of ErbB2-induced mammary tumors in transgenic mice by promoting the activation of c-Jun and STAT3. These observations offer novel mechanistic insight into ErbB2 action and highlight the notion that ErbB2 co-opts the functions of other signaling proteins to elicit tumor progression.
Original language | English (US) |
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Pages (from-to) | 93-95 |
Number of pages | 3 |
Journal | Cancer Cell |
Volume | 10 |
Issue number | 2 |
DOIs | |
State | Published - Aug 2006 |
ASJC Scopus subject areas
- Cancer Research
- Cell Biology
- Oncology