Co-opted integrin signaling in ErbB2-induced mammary tumor progression

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Although almost two decades of study point to a central role for aberrant ErbB2 activation in breast cancer, many cellular and biochemical mechanisms underlying ErbB2-induced tumor initiation and progression remain to be resolved. A study by Guo et al. published recently in Cell indicates that the signaling function of β4 integrin actively contributes to the initiation, growth, and invasion of ErbB2-induced mammary tumors in transgenic mice by promoting the activation of c-Jun and STAT3. These observations offer novel mechanistic insight into ErbB2 action and highlight the notion that ErbB2 co-opts the functions of other signaling proteins to elicit tumor progression.

Original languageEnglish (US)
Pages (from-to)93-95
Number of pages3
JournalCancer Cell
Volume10
Issue number2
DOIs
StatePublished - Aug 2006

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

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