Abstract
Although almost two decades of study point to a central role for aberrant ErbB2 activation in breast cancer, many cellular and biochemical mechanisms underlying ErbB2-induced tumor initiation and progression remain to be resolved. A study by Guo et al. published recently in Cell indicates that the signaling function of β4 integrin actively contributes to the initiation, growth, and invasion of ErbB2-induced mammary tumors in transgenic mice by promoting the activation of c-Jun and STAT3. These observations offer novel mechanistic insight into ErbB2 action and highlight the notion that ErbB2 co-opts the functions of other signaling proteins to elicit tumor progression.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 93-95 |
| Number of pages | 3 |
| Journal | Cancer Cell |
| Volume | 10 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 2006 |
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ASJC Scopus subject areas
- Cancer Research
- Cell Biology
- Oncology
Cite this
Co-opted integrin signaling in ErbB2-induced mammary tumor progression. / Carraway, Kermit L; Sweeney, Colleen A.
In: Cancer Cell, Vol. 10, No. 2, 08.2006, p. 93-95.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Co-opted integrin signaling in ErbB2-induced mammary tumor progression
AU - Carraway, Kermit L
AU - Sweeney, Colleen A
PY - 2006/8
Y1 - 2006/8
N2 - Although almost two decades of study point to a central role for aberrant ErbB2 activation in breast cancer, many cellular and biochemical mechanisms underlying ErbB2-induced tumor initiation and progression remain to be resolved. A study by Guo et al. published recently in Cell indicates that the signaling function of β4 integrin actively contributes to the initiation, growth, and invasion of ErbB2-induced mammary tumors in transgenic mice by promoting the activation of c-Jun and STAT3. These observations offer novel mechanistic insight into ErbB2 action and highlight the notion that ErbB2 co-opts the functions of other signaling proteins to elicit tumor progression.
AB - Although almost two decades of study point to a central role for aberrant ErbB2 activation in breast cancer, many cellular and biochemical mechanisms underlying ErbB2-induced tumor initiation and progression remain to be resolved. A study by Guo et al. published recently in Cell indicates that the signaling function of β4 integrin actively contributes to the initiation, growth, and invasion of ErbB2-induced mammary tumors in transgenic mice by promoting the activation of c-Jun and STAT3. These observations offer novel mechanistic insight into ErbB2 action and highlight the notion that ErbB2 co-opts the functions of other signaling proteins to elicit tumor progression.
UR - http://www.scopus.com/inward/record.url?scp=33746849303&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746849303&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2006.07.015
DO - 10.1016/j.ccr.2006.07.015
M3 - Article
C2 - 16904607
AN - SCOPUS:33746849303
VL - 10
SP - 93
EP - 95
JO - Cancer Cell
JF - Cancer Cell
SN - 1535-6108
IS - 2
ER -