Co-existence of galanin and acetylcholine: is galanin involved in memory processes and dementia?

Jacqueline Crawley, Gary L. Wenk

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

Galanin-like immunoreactivity co-exists with choline acetyltransferaselike immunoreactivity in neurons of the septal-hippocampal and nucleus basalis of Meynert-neocortical pathways. These structures mediate some forms of cognition, and characteristically degenerate in Alzheimer's disease. Biochemical, neurophysiological and behavioral studies indicate that galanin acts as an inhibitory modulator of cholinergic function. In this article, we consider the possibility of a role for galanin in memory processes and dementia.

Original languageEnglish (US)
Pages (from-to)278-282
Number of pages5
JournalTrends in Neurosciences
Volume12
Issue number8
DOIs
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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