CNTF and retina

Rong Wen, Weng Tao, Yiwen Li, Paul A. Sieving

Research output: Contribution to journalReview articlepeer-review

Abstract

Ciliary neurotrophic factor (CNTF) is one of the most studied neurotrophic factors for neuroprotection of the retina. A large body of evidence demonstrates that CNTF promotes rod photoreceptor survival in almost all animal models. Recent studies indicate that CNTF also promotes cone photoreceptor survival and cone outer segment regeneration in the degenerating retina and improves cone function in dogs with congenital achromotopsia. In addition, CNTF is a neuroprotective factor and an axogenesis factor for retinal ganglion cells (RGCs). This review focuses on the effects of exogenous CNTF on photoreceptors and RGCs in the mammalian retina and the potential clinical application of CNTF for retinal degenerative diseases.

Original languageEnglish (US)
Pages (from-to)136-151
Number of pages16
JournalProgress in Retinal and Eye Research
Volume31
Issue number2
DOIs
StatePublished - Mar 2012
Externally publishedYes

Keywords

  • CNTF
  • Neuroprotection
  • Photoreceptor plasticity
  • Photoreceptors
  • Retinal degeneration
  • Retinal ganglion cells

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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