CNS effects of circulating CCK8: involvement of brainstem neurones responding to gastric distension

Helen E Raybould, R. J. Gayton, G. J. Dockray

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Cholecystokinin octapeptide (CCK8) given i.v. or i.p. produces a variety ofbehavioural and CNS effects; these actions are probably exerted at a peripheral site but the neuronal pathways involved are uncertain. We show here that i.v. CCK8 acts on neurones in the n. tractus solitarius with an input from the stomach; cells are either or depressed by CCK8 and gastric distension, and responses to the two stimuli are always in the same direction. The responses to closearterial injection of CCK8 indicate a site of action within the splanchnic bed, and most probably a direct action on the vagal afferents mediating gastric mechanoreceptor discharge.

Original languageEnglish (US)
Pages (from-to)187-190
Number of pages4
JournalBrain Research
Volume342
Issue number1
DOIs
StatePublished - Sep 2 1985
Externally publishedYes

Keywords

  • brainstem neurones
  • CCK8
  • gastric distension
  • satiety

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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