Cluster of genes controlling proline degradation in Salmonella typhimurium

B. Ratzkin, J. Roth

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


A cluster of genes essential for degradation of proline to glutamate (put) is located between the pyrC and pyrD loci at min 22 of the Salmonella chromosome. A series of 25 deletion mutants of this region was isolated and used to construct a fine-structure map of the put genes. The map includes mutations affecting the proline degradative activities, proline oxidase and pyrroline-5-carboxylic dehydrogenase. Also included are mutations affecting the major proline permease and a regulatory mutation that affects both enzyme and permease production. The two enzymatic activities appear to be encoded by a single gene (putA). The regulatory mutation maps between the putA gene and the proline permease gene (putP).

Original languageEnglish (US)
Pages (from-to)744-754
Number of pages11
JournalJournal of Bacteriology
Issue number2
StatePublished - 1978

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology


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