Cluster analysis of risk factor genetic polymorphisms in alzheimer's disease

C. N. Randall; D. Strasburger; J. Prozonic; S. N. Morris; A. D. Winkie; G. R. Parker; Danny Cheng; E. M. Fennell; I. Lanham; N. Vakil; J. Huang; H. Cathcart; R. Huang; S. E. Poduslo

doi:10.1007/s11064-008-9626-8

Cluster analysis of risk factor genetic polymorphisms in alzheimer's disease

C. N. Randall, D. Strasburger, J. Prozonic, S. N. Morris, A. D. Winkie, G. R. Parker, Danny Cheng, E. M. Fennell, I. Lanham, N. Vakil, J. Huang, H. Cathcart, R. Huang, S. E. Poduslo

Research output: Contribution to journal › Article

15 Scopus citations

Abstract

Multiple genetic variants may contribute to the risk of developing Alzheimer's disease. We have analyzed polymorphisms in 9 genes to determine whether particular combinations would contribute to this risk. The genes were APOE, LDLr, CST3, CTSD, TNF, BACE1, MAPT, STH, eNOS, and TFCP2. Three risk groups for the disease were identified. Risk group I was younger, was heterozygous for the CST3 (GA), CTSD2936 (AG), TNF -308 (AG) genetic variants. Risk group II was older, was homozygous for the -427 APOE promoter polymorphism (TT), and heterozygous for the MAPT deletion and for the STH variant (QR). Group III had both the youngest and oldest subjects, were heterozygous for the -863 (AC) and -1031 (CT) TNF promoter polymorphisms. All three groups carried the APOE 4 allele and were heterozygous for both BACE1 polymorphisms. The control groups were carriers of the APOE 3 allele and were homozygous for the BACE1 genetic variants.

Original language	English (US)
Pages (from-to)	23-28
Number of pages	6
Journal	Neurochemical Research
Volume	34
Issue number	1
DOIs	https://doi.org/10.1007/s11064-008-9626-8
State	Published - Jan 1 2009
Externally published	Yes

Keywords

Alzheimer's disease
Cluster analysis
Genetic variants
Risk factors

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

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Cluster analysis of risk factor genetic polymorphisms in alzheimer's disease. / Randall, C. N.; Strasburger, D.; Prozonic, J.; Morris, S. N.; Winkie, A. D.; Parker, G. R.; Cheng, Danny; Fennell, E. M.; Lanham, I.; Vakil, N.; Huang, J.; Cathcart, H.; Huang, R.; Poduslo, S. E.

In: Neurochemical Research, Vol. 34, No. 1, 01.01.2009, p. 23-28.

Research output: Contribution to journal › Article

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