Cluster analysis of risk factor genetic polymorphisms in alzheimer's disease

C. N. Randall, D. Strasburger, J. Prozonic, S. N. Morris, A. D. Winkie, G. R. Parker, Danny Cheng, E. M. Fennell, I. Lanham, N. Vakil, J. Huang, H. Cathcart, R. Huang, S. E. Poduslo

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Multiple genetic variants may contribute to the risk of developing Alzheimer's disease. We have analyzed polymorphisms in 9 genes to determine whether particular combinations would contribute to this risk. The genes were APOE, LDLr, CST3, CTSD, TNF, BACE1, MAPT, STH, eNOS, and TFCP2. Three risk groups for the disease were identified. Risk group I was younger, was heterozygous for the CST3 (GA), CTSD2936 (AG), TNF -308 (AG) genetic variants. Risk group II was older, was homozygous for the -427 APOE promoter polymorphism (TT), and heterozygous for the MAPT deletion and for the STH variant (QR). Group III had both the youngest and oldest subjects, were heterozygous for the -863 (AC) and -1031 (CT) TNF promoter polymorphisms. All three groups carried the APOE 4 allele and were heterozygous for both BACE1 polymorphisms. The control groups were carriers of the APOE 3 allele and were homozygous for the BACE1 genetic variants.

Original languageEnglish (US)
Pages (from-to)23-28
Number of pages6
JournalNeurochemical Research
Volume34
Issue number1
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Cluster analysis
  • Genetic variants
  • Risk factors

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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