Abstract
Multiple genetic variants may contribute to the risk of developing Alzheimer's disease. We have analyzed polymorphisms in 9 genes to determine whether particular combinations would contribute to this risk. The genes were APOE, LDLr, CST3, CTSD, TNF, BACE1, MAPT, STH, eNOS, and TFCP2. Three risk groups for the disease were identified. Risk group I was younger, was heterozygous for the CST3 (GA), CTSD2936 (AG), TNF -308 (AG) genetic variants. Risk group II was older, was homozygous for the -427 APOE promoter polymorphism (TT), and heterozygous for the MAPT deletion and for the STH variant (QR). Group III had both the youngest and oldest subjects, were heterozygous for the -863 (AC) and -1031 (CT) TNF promoter polymorphisms. All three groups carried the APOE 4 allele and were heterozygous for both BACE1 polymorphisms. The control groups were carriers of the APOE 3 allele and were homozygous for the BACE1 genetic variants.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 23-28 |
| Number of pages | 6 |
| Journal | Neurochemical Research |
| Volume | 34 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2009 |
| Externally published | Yes |
Fingerprint
Keywords
- Alzheimer's disease
- Cluster analysis
- Genetic variants
- Risk factors
ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience
Cite this
Cluster analysis of risk factor genetic polymorphisms in alzheimer's disease. / Randall, C. N.; Strasburger, D.; Prozonic, J.; Morris, S. N.; Winkie, A. D.; Parker, G. R.; Cheng, Danny; Fennell, E. M.; Lanham, I.; Vakil, N.; Huang, J.; Cathcart, H.; Huang, R.; Poduslo, S. E.
In: Neurochemical Research, Vol. 34, No. 1, 01.01.2009, p. 23-28.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cluster analysis of risk factor genetic polymorphisms in alzheimer's disease
AU - Randall, C. N.
AU - Strasburger, D.
AU - Prozonic, J.
AU - Morris, S. N.
AU - Winkie, A. D.
AU - Parker, G. R.
AU - Cheng, Danny
AU - Fennell, E. M.
AU - Lanham, I.
AU - Vakil, N.
AU - Huang, J.
AU - Cathcart, H.
AU - Huang, R.
AU - Poduslo, S. E.
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Multiple genetic variants may contribute to the risk of developing Alzheimer's disease. We have analyzed polymorphisms in 9 genes to determine whether particular combinations would contribute to this risk. The genes were APOE, LDLr, CST3, CTSD, TNF, BACE1, MAPT, STH, eNOS, and TFCP2. Three risk groups for the disease were identified. Risk group I was younger, was heterozygous for the CST3 (GA), CTSD2936 (AG), TNF -308 (AG) genetic variants. Risk group II was older, was homozygous for the -427 APOE promoter polymorphism (TT), and heterozygous for the MAPT deletion and for the STH variant (QR). Group III had both the youngest and oldest subjects, were heterozygous for the -863 (AC) and -1031 (CT) TNF promoter polymorphisms. All three groups carried the APOE 4 allele and were heterozygous for both BACE1 polymorphisms. The control groups were carriers of the APOE 3 allele and were homozygous for the BACE1 genetic variants.
AB - Multiple genetic variants may contribute to the risk of developing Alzheimer's disease. We have analyzed polymorphisms in 9 genes to determine whether particular combinations would contribute to this risk. The genes were APOE, LDLr, CST3, CTSD, TNF, BACE1, MAPT, STH, eNOS, and TFCP2. Three risk groups for the disease were identified. Risk group I was younger, was heterozygous for the CST3 (GA), CTSD2936 (AG), TNF -308 (AG) genetic variants. Risk group II was older, was homozygous for the -427 APOE promoter polymorphism (TT), and heterozygous for the MAPT deletion and for the STH variant (QR). Group III had both the youngest and oldest subjects, were heterozygous for the -863 (AC) and -1031 (CT) TNF promoter polymorphisms. All three groups carried the APOE 4 allele and were heterozygous for both BACE1 polymorphisms. The control groups were carriers of the APOE 3 allele and were homozygous for the BACE1 genetic variants.
KW - Alzheimer's disease
KW - Cluster analysis
KW - Genetic variants
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=58149465729&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58149465729&partnerID=8YFLogxK
U2 - 10.1007/s11064-008-9626-8
DO - 10.1007/s11064-008-9626-8
M3 - Article
C2 - 18307033
AN - SCOPUS:58149465729
VL - 34
SP - 23
EP - 28
JO - Neurochemical Research
JF - Neurochemical Research
SN - 0364-3190
IS - 1
ER -