Clotting activity of polyphosphate-functionalized silica Nanoparticles

Damien Kudela, Stephanie A. Smith, Anna May-Masnou, Gary B. Braun, Alessia Pallaoro, Chi K. Nguyen, Tracy T. Chuong, Sara Nownes, Riley Allen, Nicholas R. Parker, Hooman Rashidi, James H. Morrissey, Galen D. Stucky

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that accelerates the natural clotting process of the body. SNPs initiate the contact pathway of the blood-clotting system; short-chain polyP accelerates the common pathway by the rapid formation of thrombin, which enhances the overall blood-clotting system, both by accelerating fibrin generation and by facilitating the regulatory anticoagulation mechanisms essential for hemostasis. Analysis of the clotting properties of bare SNPs, bare polyP, and polyP-functionalized SNPs in plasma demonstrated that the attachment of polyP to SNPs to form polyP-SNPs creates a substantially enhanced synergistic effect that lowers clotting time and increases thrombin production at low concentrations. PolyP-SNP even retains its clotting function at ambient temperature. The polyP-SNP system has the potential to significantly improve trauma-treatment protocols and outcomes in hospital and prehospital settings.

Original languageEnglish (US)
Pages (from-to)4018-4022
Number of pages5
JournalAngewandte Chemie - International Edition
Volume54
Issue number13
DOIs
StatePublished - Mar 23 2015

Fingerprint

Polyphosphates
Silicon Dioxide
Silica
Nanoparticles
Blood
Thrombin
Plasmas
Fibrin
Temperature

Keywords

  • hemorrhage
  • nanoparticles
  • polyphosphates
  • silicates
  • trauma

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Kudela, D., Smith, S. A., May-Masnou, A., Braun, G. B., Pallaoro, A., Nguyen, C. K., ... Stucky, G. D. (2015). Clotting activity of polyphosphate-functionalized silica Nanoparticles. Angewandte Chemie - International Edition, 54(13), 4018-4022. https://doi.org/10.1002/anie.201409639

Clotting activity of polyphosphate-functionalized silica Nanoparticles. / Kudela, Damien; Smith, Stephanie A.; May-Masnou, Anna; Braun, Gary B.; Pallaoro, Alessia; Nguyen, Chi K.; Chuong, Tracy T.; Nownes, Sara; Allen, Riley; Parker, Nicholas R.; Rashidi, Hooman; Morrissey, James H.; Stucky, Galen D.

In: Angewandte Chemie - International Edition, Vol. 54, No. 13, 23.03.2015, p. 4018-4022.

Research output: Contribution to journalArticle

Kudela, D, Smith, SA, May-Masnou, A, Braun, GB, Pallaoro, A, Nguyen, CK, Chuong, TT, Nownes, S, Allen, R, Parker, NR, Rashidi, H, Morrissey, JH & Stucky, GD 2015, 'Clotting activity of polyphosphate-functionalized silica Nanoparticles', Angewandte Chemie - International Edition, vol. 54, no. 13, pp. 4018-4022. https://doi.org/10.1002/anie.201409639
Kudela D, Smith SA, May-Masnou A, Braun GB, Pallaoro A, Nguyen CK et al. Clotting activity of polyphosphate-functionalized silica Nanoparticles. Angewandte Chemie - International Edition. 2015 Mar 23;54(13):4018-4022. https://doi.org/10.1002/anie.201409639
Kudela, Damien ; Smith, Stephanie A. ; May-Masnou, Anna ; Braun, Gary B. ; Pallaoro, Alessia ; Nguyen, Chi K. ; Chuong, Tracy T. ; Nownes, Sara ; Allen, Riley ; Parker, Nicholas R. ; Rashidi, Hooman ; Morrissey, James H. ; Stucky, Galen D. / Clotting activity of polyphosphate-functionalized silica Nanoparticles. In: Angewandte Chemie - International Edition. 2015 ; Vol. 54, No. 13. pp. 4018-4022.
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