Clotting activity of polyphosphate-functionalized silica Nanoparticles

Damien Kudela, Stephanie A. Smith, Anna May-Masnou, Gary B. Braun, Alessia Pallaoro, Chi K. Nguyen, Tracy T. Chuong, Sara Nownes, Riley Allen, Nicholas R. Parker, Hooman Rashidi, James H. Morrissey, Galen D. Stucky

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

We present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that accelerates the natural clotting process of the body. SNPs initiate the contact pathway of the blood-clotting system; short-chain polyP accelerates the common pathway by the rapid formation of thrombin, which enhances the overall blood-clotting system, both by accelerating fibrin generation and by facilitating the regulatory anticoagulation mechanisms essential for hemostasis. Analysis of the clotting properties of bare SNPs, bare polyP, and polyP-functionalized SNPs in plasma demonstrated that the attachment of polyP to SNPs to form polyP-SNPs creates a substantially enhanced synergistic effect that lowers clotting time and increases thrombin production at low concentrations. PolyP-SNP even retains its clotting function at ambient temperature. The polyP-SNP system has the potential to significantly improve trauma-treatment protocols and outcomes in hospital and prehospital settings.

Original languageEnglish (US)
Pages (from-to)4018-4022
Number of pages5
JournalAngewandte Chemie - International Edition
Volume54
Issue number13
DOIs
StatePublished - Mar 23 2015

Keywords

  • hemorrhage
  • nanoparticles
  • polyphosphates
  • silicates
  • trauma

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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    Kudela, D., Smith, S. A., May-Masnou, A., Braun, G. B., Pallaoro, A., Nguyen, C. K., Chuong, T. T., Nownes, S., Allen, R., Parker, N. R., Rashidi, H., Morrissey, J. H., & Stucky, G. D. (2015). Clotting activity of polyphosphate-functionalized silica Nanoparticles. Angewandte Chemie - International Edition, 54(13), 4018-4022. https://doi.org/10.1002/anie.201409639