Clostridium piliforme infection in two farm-raised white-tailed deer fawns (Odocoileus virginianus) and association with copper toxicosis

J. W. Brooks, M. T. Whary, A. L. Hattel, D. P. Shaw, Z. Ge, J. G. Fox, R. H. Poppenga

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Necropsy of 2 white-tailed deer fawns who died acutely revealed diarrhea and melena in case No. 1 and no gross changes in case No. 2. Histologically, the livers of both deer displayed multifocal coagulative necrosis, with infiltrations of neutrophils, macrophages, and lymphocytes. By Warthin-Starry staining, bundles of filamentous bacteria were identified within hepatocytes at the periphery of the necrotic foci in case No. 1. There was multifocal myocardiocyte necrosis in case No. 1 and multifocal lymphoid necrosis of the Peyer's patches in case No. 2. Clostridium piliforme 16S ribosomal ribonucleic acid gene was detected in both livers by polymerase chain reaction (PCR) with C. piliforme-specific primers. The liver copper levels in both cases were normal to slightly elevated. The kidney copper level in case No. 2 was elevated. This represents the first published cases of Tyzzer's disease in deer, a novel use of PCR for the diagnosis of C. piliforme infection, and a possible association between copper toxicosis and Tyzzer's disease.

Original languageEnglish (US)
Pages (from-to)765-768
Number of pages4
JournalVeterinary Pathology
Volume43
Issue number5
DOIs
StatePublished - 2006

Fingerprint

Clostridium piliforme
Clostridium Infections
fawns
Deer
Odocoileus virginianus
poisoning
Copper
necrosis
Necrosis
copper
farms
deer
liver
Liver
polymerase chain reaction
infection
Melena
Peyer's Patches
Polymerase Chain Reaction
Peyer's patches

Keywords

  • Clostridium piliforme
  • Copper
  • Deer
  • PCR
  • Tyzzer's disease

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Clostridium piliforme infection in two farm-raised white-tailed deer fawns (Odocoileus virginianus) and association with copper toxicosis. / Brooks, J. W.; Whary, M. T.; Hattel, A. L.; Shaw, D. P.; Ge, Z.; Fox, J. G.; Poppenga, R. H.

In: Veterinary Pathology, Vol. 43, No. 5, 2006, p. 765-768.

Research output: Contribution to journalArticle

Brooks, J. W. ; Whary, M. T. ; Hattel, A. L. ; Shaw, D. P. ; Ge, Z. ; Fox, J. G. ; Poppenga, R. H. / Clostridium piliforme infection in two farm-raised white-tailed deer fawns (Odocoileus virginianus) and association with copper toxicosis. In: Veterinary Pathology. 2006 ; Vol. 43, No. 5. pp. 765-768.
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