Clostridium perfringens type A-E toxin plasmids

John C. Freedman, James R. Theoret, Jessica A. Wisniewski, Francisco A Uzal, Julian I. Rood, Bruce A. McClane

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Clostridium perfringens relies upon plasmid-encoded toxin genes to cause intestinal infections. These toxin genes are associated with insertion sequences that may facilitate their mobilization and transfer, giving rise to new toxin plasmids with common backbones. Most toxin plasmids carry a transfer of clostridial plasmids locus mediating conjugation, which likely explains the presence of similar toxin plasmids in otherwise unrelated C. perfringens strains. The association of many toxin genes with insertion sequences and conjugative plasmids provides virulence flexibility when causing intestinal infections. However, incompatibility issues apparently limit the number of toxin plasmids maintained by a single cell.

Original languageEnglish (US)
Pages (from-to)264-279
Number of pages16
JournalResearch in Microbiology
Volume166
Issue number4
DOIs
StatePublished - May 1 2015

Keywords

  • Clostridia
  • Conjugation
  • Gastrointestinal disease
  • Plasmid evolution
  • Plasmid-encoded toxin

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Clostridium perfringens type A-E toxin plasmids'. Together they form a unique fingerprint.

  • Cite this

    Freedman, J. C., Theoret, J. R., Wisniewski, J. A., Uzal, F. A., Rood, J. I., & McClane, B. A. (2015). Clostridium perfringens type A-E toxin plasmids. Research in Microbiology, 166(4), 264-279. https://doi.org/10.1016/j.resmic.2014.09.004