Clostridial enteric infections in pigs

J. Glenn Songer, Francisco A Uzal

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

Clostridium perfringens types A and C and Clostridium difficile are the principal enteric clostridial pathogens of swine. History, clinical signs of disease, and gross and microscopic findings form the basis for a presumptive diagnosis of C. perfringens type-C enteritis. Confirmation is based on isolation of large numbers of type-C C. perfringens and/or detection of beta toxin in intestinal contents. Diagnosis of C. perfringens type-A infection, however, remains controversial, mostly because the condition has not been well defined and because type-A organisms and their most important major (alpha) toxin can be found in intestinal contents of healthy and diseased pigs. Isolation of large numbers of C. perfringens type A from intestinal contents, in the absence of other enteric pathogens, is the most reliable criterion on which to base a diagnosis. Recently, beta2 (CPB2) toxin-producing C. perfringens type A has been linked to disease in piglets and other animals. However, implication of CPB2 in pathogenesis of porcine infections is based principally on isolation of C. perfringens carrying cpb2, the gene encoding CPB2, and the specific role of CPB2 in enteric disease of pigs remains to be fully defined. Clostridium difficile can also be a normal inhabitant of the intestine of healthy pigs, and diagnosis of enteric infection with this microorganism is based on detection of its toxins in feces or intestinal contents.

Original languageEnglish (US)
Pages (from-to)528-536
Number of pages9
JournalJournal of Veterinary Diagnostic Investigation
Volume17
Issue number6
StatePublished - Nov 2005

Fingerprint

Clostridium perfringens
Clostridium perfringens A
Swine
Gastrointestinal Contents
toxins
swine
Clostridium perfringens C
Clostridium difficile
Infection
infection
pathogens
enteritis
digestive system diseases
Intestinal Diseases
piglets
Enteritis
intestines
pathogenesis
feces
Feces

Keywords

  • Clostridium difficile
  • Clostridium perfringens
  • Enteric infection
  • Necrotic enteritis
  • Pigs

ASJC Scopus subject areas

  • Microbiology
  • veterinary(all)

Cite this

Clostridial enteric infections in pigs. / Songer, J. Glenn; Uzal, Francisco A.

In: Journal of Veterinary Diagnostic Investigation, Vol. 17, No. 6, 11.2005, p. 528-536.

Research output: Contribution to journalArticle

@article{6de1fa4408ec4808a18989bf9c76efb4,
title = "Clostridial enteric infections in pigs",
abstract = "Clostridium perfringens types A and C and Clostridium difficile are the principal enteric clostridial pathogens of swine. History, clinical signs of disease, and gross and microscopic findings form the basis for a presumptive diagnosis of C. perfringens type-C enteritis. Confirmation is based on isolation of large numbers of type-C C. perfringens and/or detection of beta toxin in intestinal contents. Diagnosis of C. perfringens type-A infection, however, remains controversial, mostly because the condition has not been well defined and because type-A organisms and their most important major (alpha) toxin can be found in intestinal contents of healthy and diseased pigs. Isolation of large numbers of C. perfringens type A from intestinal contents, in the absence of other enteric pathogens, is the most reliable criterion on which to base a diagnosis. Recently, beta2 (CPB2) toxin-producing C. perfringens type A has been linked to disease in piglets and other animals. However, implication of CPB2 in pathogenesis of porcine infections is based principally on isolation of C. perfringens carrying cpb2, the gene encoding CPB2, and the specific role of CPB2 in enteric disease of pigs remains to be fully defined. Clostridium difficile can also be a normal inhabitant of the intestine of healthy pigs, and diagnosis of enteric infection with this microorganism is based on detection of its toxins in feces or intestinal contents.",
keywords = "Clostridium difficile, Clostridium perfringens, Enteric infection, Necrotic enteritis, Pigs",
author = "Songer, {J. Glenn} and Uzal, {Francisco A}",
year = "2005",
month = "11",
language = "English (US)",
volume = "17",
pages = "528--536",
journal = "Journal of Veterinary Diagnostic Investigation",
issn = "1040-6387",
publisher = "American Association of Veterinary Laboratory Diagnosticians",
number = "6",

}

TY - JOUR

T1 - Clostridial enteric infections in pigs

AU - Songer, J. Glenn

AU - Uzal, Francisco A

PY - 2005/11

Y1 - 2005/11

N2 - Clostridium perfringens types A and C and Clostridium difficile are the principal enteric clostridial pathogens of swine. History, clinical signs of disease, and gross and microscopic findings form the basis for a presumptive diagnosis of C. perfringens type-C enteritis. Confirmation is based on isolation of large numbers of type-C C. perfringens and/or detection of beta toxin in intestinal contents. Diagnosis of C. perfringens type-A infection, however, remains controversial, mostly because the condition has not been well defined and because type-A organisms and their most important major (alpha) toxin can be found in intestinal contents of healthy and diseased pigs. Isolation of large numbers of C. perfringens type A from intestinal contents, in the absence of other enteric pathogens, is the most reliable criterion on which to base a diagnosis. Recently, beta2 (CPB2) toxin-producing C. perfringens type A has been linked to disease in piglets and other animals. However, implication of CPB2 in pathogenesis of porcine infections is based principally on isolation of C. perfringens carrying cpb2, the gene encoding CPB2, and the specific role of CPB2 in enteric disease of pigs remains to be fully defined. Clostridium difficile can also be a normal inhabitant of the intestine of healthy pigs, and diagnosis of enteric infection with this microorganism is based on detection of its toxins in feces or intestinal contents.

AB - Clostridium perfringens types A and C and Clostridium difficile are the principal enteric clostridial pathogens of swine. History, clinical signs of disease, and gross and microscopic findings form the basis for a presumptive diagnosis of C. perfringens type-C enteritis. Confirmation is based on isolation of large numbers of type-C C. perfringens and/or detection of beta toxin in intestinal contents. Diagnosis of C. perfringens type-A infection, however, remains controversial, mostly because the condition has not been well defined and because type-A organisms and their most important major (alpha) toxin can be found in intestinal contents of healthy and diseased pigs. Isolation of large numbers of C. perfringens type A from intestinal contents, in the absence of other enteric pathogens, is the most reliable criterion on which to base a diagnosis. Recently, beta2 (CPB2) toxin-producing C. perfringens type A has been linked to disease in piglets and other animals. However, implication of CPB2 in pathogenesis of porcine infections is based principally on isolation of C. perfringens carrying cpb2, the gene encoding CPB2, and the specific role of CPB2 in enteric disease of pigs remains to be fully defined. Clostridium difficile can also be a normal inhabitant of the intestine of healthy pigs, and diagnosis of enteric infection with this microorganism is based on detection of its toxins in feces or intestinal contents.

KW - Clostridium difficile

KW - Clostridium perfringens

KW - Enteric infection

KW - Necrotic enteritis

KW - Pigs

UR - http://www.scopus.com/inward/record.url?scp=27944450074&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27944450074&partnerID=8YFLogxK

M3 - Article

C2 - 16475510

AN - SCOPUS:27944450074

VL - 17

SP - 528

EP - 536

JO - Journal of Veterinary Diagnostic Investigation

JF - Journal of Veterinary Diagnostic Investigation

SN - 1040-6387

IS - 6

ER -