Abstract
Objective: To evaluate the effect of clopidogrel on the rate of thrombosis in a rat model for venous microvascular failure. Study Design and Setting: Forty rats were treated with clopidogrel or saline control via gastric gavage in a randomized, blinded fashion. After allowing for absorption and activation, each femoral vein was isolated and a venous "tuck" procedure was performed. The bleeding time and vessel patency were subsequently evaluated. Results: The rate of vessel thrombosis was decreased in the clopidogrel-treated group compared to controls (7.9% vs 31.4%, P < 0.025). The bleeding time was longer in the clopidogrel-treated group compared to controls (250 ± 100 seconds vs 173 ± 59 seconds, P < 0.015). Conclusion: Clopidogrel decreased the rate of thrombosis in the rat model for venous microvascular failure. Significance: The use of clopidogrel may reduce the rate of venous thrombosis after free tissue transfer and may be indicated in select patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 573-576 |
| Number of pages | 4 |
| Journal | Otolaryngology - Head and Neck Surgery |
| Volume | 136 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2007 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Surgery
- Otorhinolaryngology
Cite this
Clopidogrel (Plavix) reduces the rate of thrombosis in the rat tuck model for microvenous anastomosis. / Moore, Michael; Deschler, Daniel G.
In: Otolaryngology - Head and Neck Surgery, Vol. 136, No. 4, 01.04.2007, p. 573-576.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clopidogrel (Plavix) reduces the rate of thrombosis in the rat tuck model for microvenous anastomosis
AU - Moore, Michael
AU - Deschler, Daniel G.
PY - 2007/4/1
Y1 - 2007/4/1
N2 - Objective: To evaluate the effect of clopidogrel on the rate of thrombosis in a rat model for venous microvascular failure. Study Design and Setting: Forty rats were treated with clopidogrel or saline control via gastric gavage in a randomized, blinded fashion. After allowing for absorption and activation, each femoral vein was isolated and a venous "tuck" procedure was performed. The bleeding time and vessel patency were subsequently evaluated. Results: The rate of vessel thrombosis was decreased in the clopidogrel-treated group compared to controls (7.9% vs 31.4%, P < 0.025). The bleeding time was longer in the clopidogrel-treated group compared to controls (250 ± 100 seconds vs 173 ± 59 seconds, P < 0.015). Conclusion: Clopidogrel decreased the rate of thrombosis in the rat model for venous microvascular failure. Significance: The use of clopidogrel may reduce the rate of venous thrombosis after free tissue transfer and may be indicated in select patients.
AB - Objective: To evaluate the effect of clopidogrel on the rate of thrombosis in a rat model for venous microvascular failure. Study Design and Setting: Forty rats were treated with clopidogrel or saline control via gastric gavage in a randomized, blinded fashion. After allowing for absorption and activation, each femoral vein was isolated and a venous "tuck" procedure was performed. The bleeding time and vessel patency were subsequently evaluated. Results: The rate of vessel thrombosis was decreased in the clopidogrel-treated group compared to controls (7.9% vs 31.4%, P < 0.025). The bleeding time was longer in the clopidogrel-treated group compared to controls (250 ± 100 seconds vs 173 ± 59 seconds, P < 0.015). Conclusion: Clopidogrel decreased the rate of thrombosis in the rat model for venous microvascular failure. Significance: The use of clopidogrel may reduce the rate of venous thrombosis after free tissue transfer and may be indicated in select patients.
UR - http://www.scopus.com/inward/record.url?scp=34047129098&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34047129098&partnerID=8YFLogxK
U2 - 10.1016/j.otohns.2006.06.1276
DO - 10.1016/j.otohns.2006.06.1276
M3 - Article
C2 - 17418254
AN - SCOPUS:34047129098
VL - 136
SP - 573
EP - 576
JO - Otolaryngology - Head and Neck Surgery (United States)
JF - Otolaryngology - Head and Neck Surgery (United States)
SN - 0194-5998
IS - 4
ER -