Cloning, tissue distribution and function of ABCA transporters

Nobuya Inagaki, Katsuya Yamada, Li Xia Zhao, Gen Yamano, Yukiko Tanaka, Hisayuki Funahashi, Chengji Zhou, Seiji Shioda, Nobuhiro Ban

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We cloned the full-length cDNA of ABCA2. ABCA2 is expressed predominantly in the oligodendrocytes in the brain, and onset of ABCA2 expression in the oligodendrocytes coincides with the appearance of thick myelin basic protein (MBP)-immunolabeled myelin segments. Oligodendrocytes produce the lamellar structure myelin, which is composed of phospholipids and specific myelin proteins. We also cloned ABCA3 from human lung and found that ABCA3 is expressed predominantly at the limiting membrane of the lamellar bodies of alveolar type II cells in human lung. Pulmonary surfactant, composed mainly of phospholipids and specific surfactant proteins, is stored as lamellar bodies before exocytosis into the alveolar space. These data suggest that ABCA2 and ABCA3 are involved in membrane transport of substrates such as the lipids that are closely linked to myelin and surfactant formation processes.

Original languageEnglish (US)
Pages (from-to)578-581
Number of pages4
JournalInternational Congress Series
Volume1262
Issue numberC
DOIs
StatePublished - May 1 2004
Externally publishedYes

Keywords

  • ABC transporter
  • ABCA2
  • ABCA3
  • Myelin
  • Pulmonary surfactant

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Cloning, tissue distribution and function of ABCA transporters'. Together they form a unique fingerprint.

  • Cite this

    Inagaki, N., Yamada, K., Zhao, L. X., Yamano, G., Tanaka, Y., Funahashi, H., Zhou, C., Shioda, S., & Ban, N. (2004). Cloning, tissue distribution and function of ABCA transporters. International Congress Series, 1262(C), 578-581. https://doi.org/10.1016/j.ics.2003.12.049