Cloning of cDNA and Genomic DNA Encoding Human Type XVIII Collagen and Localization of the α1(XVIII) Collagen Gene to Mouse Chromosome 10 and Human Chromosome 21

Suk P. Oh, Matthew L. Warman, Michael F Seldin, Sou De Cheng, Joan H M Knoll, Sheila Timmons, Bjorn R. Olsen

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Abstract

Types XV and XVIII collagen belong to a unique and novel subclass of the collagen superfamily for which we have proposed the name the MULTIPLEXIN family. Members of this class contain polypeptides with multiple triple-helical domains separated and flanked by non-triple-helical regions. In this paper, we report the isolation of human cDNAs and genomic DNAs encoding the α1(XVIII) collagen chain. Utilizing a genomic clone as probe, we have mapped the COL18A1 gene to chromosome 21q22.3 by fluorescence in situ hybridization. In addition, using an interspecific backcross panel, we have shown that the murine Col18a1 locus is on chromosome 10, close to the loci for Col6a1 and Col6a2.

Original languageEnglish (US)
Pages (from-to)494-499
Number of pages6
JournalGenomics
Volume19
Issue number3
DOIs
StatePublished - Feb 1994
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics

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