Cloning of a novel C-type lectin expressed by murine macrophages

Signe G. Balch, Andrew J. McKnight, Michael F Seldin, Siamon Gordon

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


We report the cloning of a novel macrophage-restricted C-type lectin by differential display polymerase chain reaction. This molecule, named mouse macrophage C-type lectin, is a 219-amino acid, type II transmembrane protein with a single extracellular C-type lectin domain. Northern blot analysis indicates that it is expressed in cell lines and normal mouse tissues in a macrophage-restricted manner. The cDNA and genomic sequences of mouse macrophage C-type lectin indicate that it is related to the Group II animal C-type lectins. The mcl gene locus has been mapped between the genes for the interleukin-17 receptor and CD4 on mouse chromosome 6, the same chromosome as the mouse natural killer cell gene complex.

Original languageEnglish (US)
Pages (from-to)18656-18664
Number of pages9
JournalJournal of Biological Chemistry
Issue number29
StatePublished - Jul 17 1998

ASJC Scopus subject areas

  • Biochemistry


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