Cloning and mapping of the mouse α7-neuronal nicotinic acetylcholine receptor

Avi Orr-Urtreger, Michael F Seldin, Antonio Baldini, Arthur L. Beaudet

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

We report the isolation of cDNA clones for the mouse α7 neuronal nicotinic acetylcholine receptor subunit (gene symbol Acra7), the only nicotinic receptor subunit known to bind α-bungarotoxin in mammalian brain. This gene may have relevance to nicotine sensitivity and to some electrophysiologic findings in schizophrenia. The mouse α7 subunit gene encodes a protein of 502 amino acids with substantial identity to the rat (99.6%), human (92.8%), and chicken (87.5%) amino acid sequences. The α7 gene was mapped to mouse chromosome 7 near the p locus with the following gene order from proximal to distal: Myod1-3.5 ± 1.7 cM-Gas2-0.9 cM ± 0.9 cM-D7Mit70-1.8 ± 1.2 cM- Acra7-4.4 ± 1.0 cM-Hras1-ps1/Igf1r/Snrp2a. The human gene was confirmed to map to the homologous region of human chromosome 15q13-q14.

Original languageEnglish (US)
Pages (from-to)399-402
Number of pages4
JournalGenomics
Volume26
Issue number2
DOIs
StatePublished - Mar 20 1995
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics

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