Clonidine reversal of increased norepinephrine metabolite levels during morphine withdrawal

Jacqueline Crawley, Richard Laverty, Robert H. Roth

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

The production of the norepinephrine metabolite 3-methoxy-4-hydroxyphethylenglycol (MHPG) in brain regions innvervated by the locus coeruleus was increased during naloxone-precipitated withdrawal from chronic morphine treatment. This MHPG increases was reversed by subcutaneous administration of clonidine. Changes in MHPG levels paralleled the electrophysiological changes found by Aghajanian (1978) in locus coeruleus firing rate with similar treatments, demonstrating the usefulness of MHPG changes as an index of central noradrenergic function.

Original languageEnglish (US)
Pages (from-to)247-250
Number of pages4
JournalEuropean Journal of Pharmacology
Volume57
Issue number2-3
DOIs
StatePublished - Aug 1 1979
Externally publishedYes

Fingerprint

Locus Coeruleus
Clonidine
Morphine
Norepinephrine
Naloxone
Brain

Keywords

  • Clonidine
  • Dopamine
  • Locus coeruleus
  • Metabolites
  • Morphine
  • Norepinephrine

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Clonidine reversal of increased norepinephrine metabolite levels during morphine withdrawal. / Crawley, Jacqueline; Laverty, Richard; Roth, Robert H.

In: European Journal of Pharmacology, Vol. 57, No. 2-3, 01.08.1979, p. 247-250.

Research output: Contribution to journalArticle

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