Clonazepam blockade of spontaneous and CO2 inhalation-provoked panic in a patient with panic disorder

A. Beckett, Scott M Fishman, J. F. Rosenbaum

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


A 30-year-old woman with panic disorder and phobic avoidance responded partially to treatment with alprazolam but recovered fully while receiving clonazepam, which blocked her panic attacks and anticipatory anxiety. Before treatment, the patient underwent a carbon dioxide inhalation test as a challenge and sustained a full-featured panic attack. After clonazepam therapy and retesting under identical conditions, no panic attack was reported. This is the first report of provoked panic blocked by clonazepam, a putative, clinically effective antipanic agent.

Original languageEnglish (US)
Pages (from-to)475-476
Number of pages2
JournalJournal of Clinical Psychiatry
Issue number9
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology


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