Clonal remission in aplastic anemia after treatment with antithymocyte globulin

Theodore Wun, J. P. Lewis

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Aplastic anemia includes a group of disorders characterized by peripheral blood pancytopenia and marrow hypocellularity. The current report describes a patient who is an apparent constitutional mosaic and presented with marrow aplasia. Using cytogenetic analysis of bone marrow, skin, and peripheral T lymphocytes, we demonstrate the clonal nature of this patient's aplastic marrow, and, in addition, identify clonal evolution. The patient was treated with antithymocyte globulin (ATG) and achieved a complete remission, with disappearance of an abnormal evolved clone. This case illustrates that clonal cytogenetic abnormalities do not preclude a response to ATG and that aplastic anemia may be a nonmalignant clonal disorder with clonal evolution.

Original languageEnglish (US)
Pages (from-to)229-231
Number of pages3
JournalAmerican Journal of Hematology
Volume40
Issue number3
DOIs
StatePublished - 1992

Keywords

  • clonality
  • cytogenetics
  • immunosuppressive therapy

ASJC Scopus subject areas

  • Hematology

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