Abstract
Proliferation and differentiation of peritoneal exudate colon-forming cells (PE-CFC) were examined in BALB/c, C57BL/6, and NZB mice; NZB mice provided an experimental animal model for studies of autoimmunity. At 1 and 12 months of age, the number of PE-CFC from NZB mice was significantly less than the number of PE-CFC for other tested strains, whereas the number of clusters formed was reduced only in the older NZB mice. In contrast, 1- to 12-month-old BALB/c and C57BL/6 mice showed no significant age or strain-dependent alterations in PE-CFC. Although the latency period preceding colony growth remained constant for all strains and ages, significant variation in colony size was observed for NZB mice; the largest colonies were noted in the oldest group. We also observed age-associated variations in colony morphology; therefore, age- and strain-dependent differences may exist in the differentiation or functional attributes of PE-CFC subpopulations. The results specifically indicate that NZB mice have age-related alterations in PEC proliferative and differentiation capacities.
Original language | English (US) |
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Pages (from-to) | 209-214 |
Number of pages | 6 |
Journal | Anatomical Record |
Volume | 204 |
Issue number | 3 |
State | Published - 1982 |
ASJC Scopus subject areas
- Agricultural and Biological Sciences (miscellaneous)
- Anatomy