Clinimetric Properties of the Fragile X-associated Tremor Ataxia Syndrome Rating Scale

Deborah A. Hall, Glenn T. Stebbins, Sebastien Jacquemont, Elizabeth Berry-Kravis, Christopher G. Goetz, Randi J Hagerman, Lin Zhang, Maureen A. Leehey

Research output: Contribution to journalArticle

Abstract

Background: There are currently no proven treatments for fragile X-associated tremor and ataxia syndrome (FXTAS). Validated outcome measures are needed in order to plan and conduct clinical trials to aid in the development of therapy. Methods: This study examined the reliability and construct validity of the FXTAS Rating Scale. The study was conducted by using ratings from movement disorder specialists, who were blinded to gene status, on the FXTAS Rating Scale. Results: In 295 premutation carriers with and without FXTAS, 33 scale items showed a high level of overall reliability, adequate item-to-total correlations and construct validity. Factor analysis revealed four components. Conclusions: The result demonstrates that many items in the scale meet standard clinimetric criteria, but modification of the scale improved the overall utility.

Original languageEnglish (US)
JournalMovement Disorders Clinical Practice
DOIs
StateAccepted/In press - Jan 1 2019

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Movement Disorders
Reproducibility of Results
Statistical Factor Analysis
Outcome Assessment (Health Care)
Clinical Trials
Fragile X Tremor Ataxia Syndrome
Genes
Therapeutics

Keywords

  • FMR1
  • Fragile X-associated tremor ataxia syndrome
  • FXTAS Rating Scale

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Hall, D. A., Stebbins, G. T., Jacquemont, S., Berry-Kravis, E., Goetz, C. G., Hagerman, R. J., ... Leehey, M. A. (Accepted/In press). Clinimetric Properties of the Fragile X-associated Tremor Ataxia Syndrome Rating Scale. Movement Disorders Clinical Practice. https://doi.org/10.1002/mdc3.12708

Clinimetric Properties of the Fragile X-associated Tremor Ataxia Syndrome Rating Scale. / Hall, Deborah A.; Stebbins, Glenn T.; Jacquemont, Sebastien; Berry-Kravis, Elizabeth; Goetz, Christopher G.; Hagerman, Randi J; Zhang, Lin; Leehey, Maureen A.

In: Movement Disorders Clinical Practice, 01.01.2019.

Research output: Contribution to journalArticle

Hall, Deborah A. ; Stebbins, Glenn T. ; Jacquemont, Sebastien ; Berry-Kravis, Elizabeth ; Goetz, Christopher G. ; Hagerman, Randi J ; Zhang, Lin ; Leehey, Maureen A. / Clinimetric Properties of the Fragile X-associated Tremor Ataxia Syndrome Rating Scale. In: Movement Disorders Clinical Practice. 2019.
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AU - Goetz, Christopher G.

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AU - Zhang, Lin

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