Clinical use of recombinant human bone morphogenic protein-2 in a whooping crane (Grus americana)

Susannah Sample, Gretchen Cole, Joanne Paul-Murphy, Barry K. Hartup, Victoria Clyde, Howard J. Seeherman, Susan Schaefer

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Objective - To report use of recombinant human bone morphogenetic protein-2 (rhBMP-2) as adjunctive therapy for treatment of a comminuted, open, proximal humeral fracture in an avian species. Study Design - Clinical report. Animals - A 3.5-month-old male whooping crane (Grus americana). Methods - An open, severely comminuted humeral facture was stabilized with an intramuscular (IM) pin/type IA external skeletal fixator with tie-in configuration. rhBMP-2 was applied in a calcium phosphate matrix (CPM) paste directly to the fracture site as a bone graft substitute. Radiographic evidence of bone healing was monitored for 14 weeks. Results - Substantial bony callus was evident at 4 weeks and at 8 weeks there was bridging callus with obvious bony remodeling. The fixation was destabilized at 9 weeks by IM pin removal, bone healing progressed and the fixator was removed at 11 weeks. By 14 weeks both cortices had been re-established with continued callus remodeling evident. Conclusion - rhBMP-2, applied in a CPM paste, was used as a bone graft substitute in the treatment of a comminuted, open humeral fracture in a whooping crane. Clinical Relevance - Use of rhBMP-2/CPM should be considered in treatment of avian fractures.

Original languageEnglish (US)
Pages (from-to)552-557
Number of pages6
JournalVeterinary Surgery
Issue number6
StatePublished - Aug 2008

ASJC Scopus subject areas

  • veterinary(all)


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