TY - JOUR
T1 - Clinical use of recombinant human bone morphogenic protein-2 in a whooping crane (Grus americana)
AU - Sample, Susannah
AU - Cole, Gretchen
AU - Paul-Murphy, Joanne
AU - Hartup, Barry K.
AU - Clyde, Victoria
AU - Seeherman, Howard J.
AU - Schaefer, Susan
PY - 2008/8
Y1 - 2008/8
N2 - Objective - To report use of recombinant human bone morphogenetic protein-2 (rhBMP-2) as adjunctive therapy for treatment of a comminuted, open, proximal humeral fracture in an avian species. Study Design - Clinical report. Animals - A 3.5-month-old male whooping crane (Grus americana). Methods - An open, severely comminuted humeral facture was stabilized with an intramuscular (IM) pin/type IA external skeletal fixator with tie-in configuration. rhBMP-2 was applied in a calcium phosphate matrix (CPM) paste directly to the fracture site as a bone graft substitute. Radiographic evidence of bone healing was monitored for 14 weeks. Results - Substantial bony callus was evident at 4 weeks and at 8 weeks there was bridging callus with obvious bony remodeling. The fixation was destabilized at 9 weeks by IM pin removal, bone healing progressed and the fixator was removed at 11 weeks. By 14 weeks both cortices had been re-established with continued callus remodeling evident. Conclusion - rhBMP-2, applied in a CPM paste, was used as a bone graft substitute in the treatment of a comminuted, open humeral fracture in a whooping crane. Clinical Relevance - Use of rhBMP-2/CPM should be considered in treatment of avian fractures.
AB - Objective - To report use of recombinant human bone morphogenetic protein-2 (rhBMP-2) as adjunctive therapy for treatment of a comminuted, open, proximal humeral fracture in an avian species. Study Design - Clinical report. Animals - A 3.5-month-old male whooping crane (Grus americana). Methods - An open, severely comminuted humeral facture was stabilized with an intramuscular (IM) pin/type IA external skeletal fixator with tie-in configuration. rhBMP-2 was applied in a calcium phosphate matrix (CPM) paste directly to the fracture site as a bone graft substitute. Radiographic evidence of bone healing was monitored for 14 weeks. Results - Substantial bony callus was evident at 4 weeks and at 8 weeks there was bridging callus with obvious bony remodeling. The fixation was destabilized at 9 weeks by IM pin removal, bone healing progressed and the fixator was removed at 11 weeks. By 14 weeks both cortices had been re-established with continued callus remodeling evident. Conclusion - rhBMP-2, applied in a CPM paste, was used as a bone graft substitute in the treatment of a comminuted, open humeral fracture in a whooping crane. Clinical Relevance - Use of rhBMP-2/CPM should be considered in treatment of avian fractures.
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U2 - 10.1111/j.1532-950X.2008.00419.x
DO - 10.1111/j.1532-950X.2008.00419.x
M3 - Article
C2 - 19134105
AN - SCOPUS:49249123935
VL - 37
SP - 552
EP - 557
JO - Veterinary Surgery
JF - Veterinary Surgery
SN - 0161-3499
IS - 6
ER -