Clinical trials in pediatric traumatic brain injury: Unique challenges and potential responses

JoAnne E. Natale, Jill G. Joseph, Robert K Pretzlaff, Tomas J. Silber, Anne Marie Guerguerian

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our own experience by a mini review of similar studies, identifying challenges and possible responses from the perspective of families, investigators, funding agencies and society.

Original languageEnglish (US)
Pages (from-to)276-290
Number of pages15
JournalDevelopmental Neuroscience
Volume28
Issue number4-5
DOIs
StatePublished - Aug 2006

Keywords

  • Patient recruitment
  • Pediatric traumatic brain injury
  • Translational research

ASJC Scopus subject areas

  • Neuroscience(all)

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