Clinical trials in pediatric traumatic brain injury: Unique challenges and potential responses

JoAnne E Natale, Jill G Joseph, Robert K. Pretzlaff, Tomas J. Silber, Anne Marie Guerguerian

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our own experience by a mini review of similar studies, identifying challenges and possible responses from the perspective of families, investigators, funding agencies and society.

Original languageEnglish (US)
Pages (from-to)276-290
Number of pages15
JournalDevelopmental Neuroscience
Volume28
Issue number4-5
DOIs
StatePublished - Aug 2006

Fingerprint

Magnesium Sulfate
Translational Medical Research
Neuroprotective Agents
Research Personnel
Clinical Trials
Pediatrics
Safety
Traumatic Brain Injury

Keywords

  • Patient recruitment
  • Pediatric traumatic brain injury
  • Translational research

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Clinical trials in pediatric traumatic brain injury : Unique challenges and potential responses. / Natale, JoAnne E; Joseph, Jill G; Pretzlaff, Robert K.; Silber, Tomas J.; Guerguerian, Anne Marie.

In: Developmental Neuroscience, Vol. 28, No. 4-5, 08.2006, p. 276-290.

Research output: Contribution to journalArticle

Natale, JoAnne E ; Joseph, Jill G ; Pretzlaff, Robert K. ; Silber, Tomas J. ; Guerguerian, Anne Marie. / Clinical trials in pediatric traumatic brain injury : Unique challenges and potential responses. In: Developmental Neuroscience. 2006 ; Vol. 28, No. 4-5. pp. 276-290.
@article{026d8d64b2724f238f8398844b217c47,
title = "Clinical trials in pediatric traumatic brain injury: Unique challenges and potential responses",
abstract = "In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our own experience by a mini review of similar studies, identifying challenges and possible responses from the perspective of families, investigators, funding agencies and society.",
keywords = "Patient recruitment, Pediatric traumatic brain injury, Translational research",
author = "Natale, {JoAnne E} and Joseph, {Jill G} and Pretzlaff, {Robert K.} and Silber, {Tomas J.} and Guerguerian, {Anne Marie}",
year = "2006",
month = "8",
doi = "10.1159/000094154",
language = "English (US)",
volume = "28",
pages = "276--290",
journal = "Developmental Neuroscience",
issn = "0378-5866",
publisher = "S. Karger AG",
number = "4-5",

}

TY - JOUR

T1 - Clinical trials in pediatric traumatic brain injury

T2 - Unique challenges and potential responses

AU - Natale, JoAnne E

AU - Joseph, Jill G

AU - Pretzlaff, Robert K.

AU - Silber, Tomas J.

AU - Guerguerian, Anne Marie

PY - 2006/8

Y1 - 2006/8

N2 - In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our own experience by a mini review of similar studies, identifying challenges and possible responses from the perspective of families, investigators, funding agencies and society.

AB - In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our own experience by a mini review of similar studies, identifying challenges and possible responses from the perspective of families, investigators, funding agencies and society.

KW - Patient recruitment

KW - Pediatric traumatic brain injury

KW - Translational research

UR - http://www.scopus.com/inward/record.url?scp=33748139920&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748139920&partnerID=8YFLogxK

U2 - 10.1159/000094154

DO - 10.1159/000094154

M3 - Article

C2 - 16943651

AN - SCOPUS:33748139920

VL - 28

SP - 276

EP - 290

JO - Developmental Neuroscience

JF - Developmental Neuroscience

SN - 0378-5866

IS - 4-5

ER -