Clinical trials in pediatric traumatic brain injury: Unique challenges and potential responses

JoAnne E. Natale, Jill G. Joseph, Robert K Pretzlaff, Tomas J. Silber, Anne Marie Guerguerian

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our own experience by a mini review of similar studies, identifying challenges and possible responses from the perspective of families, investigators, funding agencies and society.

Original languageEnglish (US)
Pages (from-to)276-290
Number of pages15
JournalDevelopmental Neuroscience
Volume28
Issue number4-5
DOIs
StatePublished - Aug 2006

Keywords

  • Patient recruitment
  • Pediatric traumatic brain injury
  • Translational research

ASJC Scopus subject areas

  • Neuroscience(all)

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