Abstract
In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our own experience by a mini review of similar studies, identifying challenges and possible responses from the perspective of families, investigators, funding agencies and society.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 276-290 |
| Number of pages | 15 |
| Journal | Developmental Neuroscience |
| Volume | 28 |
| Issue number | 4-5 |
| DOIs | |
| State | Published - Aug 2006 |
Keywords
- Patient recruitment
- Pediatric traumatic brain injury
- Translational research
ASJC Scopus subject areas
- Neuroscience(all)
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Cite this
Natale, J. E., Joseph, J. G., Pretzlaff, R. K., Silber, T. J., & Guerguerian, A. M. (2006). Clinical trials in pediatric traumatic brain injury: Unique challenges and potential responses. Developmental Neuroscience, 28(4-5), 276-290. https://doi.org/10.1159/000094154