Abstract
In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our own experience by a mini review of similar studies, identifying challenges and possible responses from the perspective of families, investigators, funding agencies and society.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 276-290 |
| Number of pages | 15 |
| Journal | Developmental Neuroscience |
| Volume | 28 |
| Issue number | 4-5 |
| DOIs | |
| State | Published - Aug 2006 |
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Keywords
- Patient recruitment
- Pediatric traumatic brain injury
- Translational research
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Clinical trials in pediatric traumatic brain injury : Unique challenges and potential responses. / Natale, JoAnne E; Joseph, Jill G; Pretzlaff, Robert K.; Silber, Tomas J.; Guerguerian, Anne Marie.
In: Developmental Neuroscience, Vol. 28, No. 4-5, 08.2006, p. 276-290.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical trials in pediatric traumatic brain injury
T2 - Unique challenges and potential responses
AU - Natale, JoAnne E
AU - Joseph, Jill G
AU - Pretzlaff, Robert K.
AU - Silber, Tomas J.
AU - Guerguerian, Anne Marie
PY - 2006/8
Y1 - 2006/8
N2 - In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our own experience by a mini review of similar studies, identifying challenges and possible responses from the perspective of families, investigators, funding agencies and society.
AB - In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our own experience by a mini review of similar studies, identifying challenges and possible responses from the perspective of families, investigators, funding agencies and society.
KW - Patient recruitment
KW - Pediatric traumatic brain injury
KW - Translational research
UR - http://www.scopus.com/inward/record.url?scp=33748139920&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748139920&partnerID=8YFLogxK
U2 - 10.1159/000094154
DO - 10.1159/000094154
M3 - Article
C2 - 16943651
AN - SCOPUS:33748139920
VL - 28
SP - 276
EP - 290
JO - Developmental Neuroscience
JF - Developmental Neuroscience
SN - 0378-5866
IS - 4-5
ER -