Clinical trials in pediatric traumatic brain injury: Unique challenges and potential responses

JoAnne E. Natale; Jill G. Joseph; Robert K Pretzlaff; Tomas J. Silber; Anne Marie Guerguerian

doi:10.1159/000094154

Clinical trials in pediatric traumatic brain injury: Unique challenges and potential responses

JoAnne E. Natale, Jill G. Joseph, Robert K Pretzlaff, Tomas J. Silber, Anne Marie Guerguerian

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our own experience by a mini review of similar studies, identifying challenges and possible responses from the perspective of families, investigators, funding agencies and society.

Original language	English (US)
Pages (from-to)	276-290
Number of pages	15
Journal	Developmental Neuroscience
Volume	28
Issue number	4-5
DOIs	https://doi.org/10.1159/000094154
State	Published - Aug 2006

Keywords

Patient recruitment
Pediatric traumatic brain injury
Translational research

ASJC Scopus subject areas

Neuroscience(all)

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10.1159/000094154

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abstract = "In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our own experience by a mini review of similar studies, identifying challenges and possible responses from the perspective of families, investigators, funding agencies and society.",

keywords = "Patient recruitment, Pediatric traumatic brain injury, Translational research",

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AU - Silber, Tomas J.

AU - Guerguerian, Anne Marie

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Clinical trials in pediatric traumatic brain injury: Unique challenges and potential responses

Abstract

Keywords

ASJC Scopus subject areas

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