Clinical trials in pediatric traumatic brain injury: Unique challenges and potential responses

JoAnne E. Natale; Jill G. Joseph; Robert K Pretzlaff; Tomas J. Silber; Anne Marie Guerguerian

doi:10.1159/000094154

Clinical trials in pediatric traumatic brain injury: Unique challenges and potential responses

JoAnne E. Natale, Jill G. Joseph, Robert K Pretzlaff, Tomas J. Silber, Anne Marie Guerguerian

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our own experience by a mini review of similar studies, identifying challenges and possible responses from the perspective of families, investigators, funding agencies and society.

Original language	English (US)
Pages (from-to)	276-290
Number of pages	15
Journal	Developmental Neuroscience
Volume	28
Issue number	4-5
DOIs	https://doi.org/10.1159/000094154
State	Published - Aug 2006

Keywords

Patient recruitment
Pediatric traumatic brain injury
Translational research

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1159/000094154

Cite this

@article{026d8d64b2724f238f8398844b217c47,

title = "Clinical trials in pediatric traumatic brain injury: Unique challenges and potential responses",

abstract = "In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our own experience by a mini review of similar studies, identifying challenges and possible responses from the perspective of families, investigators, funding agencies and society.",

keywords = "Patient recruitment, Pediatric traumatic brain injury, Translational research",

author = "Natale, {JoAnne E.} and Joseph, {Jill G.} and Pretzlaff, {Robert K} and Silber, {Tomas J.} and Guerguerian, {Anne Marie}",

year = "2006",

month = aug,

doi = "10.1159/000094154",

language = "English (US)",

volume = "28",

pages = "276--290",

journal = "Developmental Neuroscience",

issn = "0378-5866",

publisher = "S. Karger AG",

number = "4-5",

}

TY - JOUR

T1 - Clinical trials in pediatric traumatic brain injury

T2 - Unique challenges and potential responses

AU - Natale, JoAnne E.

AU - Joseph, Jill G.

AU - Pretzlaff, Robert K

AU - Silber, Tomas J.

AU - Guerguerian, Anne Marie

PY - 2006/8

Y1 - 2006/8

N2 - In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our own experience by a mini review of similar studies, identifying challenges and possible responses from the perspective of families, investigators, funding agencies and society.

AB - In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our own experience by a mini review of similar studies, identifying challenges and possible responses from the perspective of families, investigators, funding agencies and society.

KW - Patient recruitment

KW - Pediatric traumatic brain injury

KW - Translational research

UR - http://www.scopus.com/inward/record.url?scp=33748139920&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748139920&partnerID=8YFLogxK

U2 - 10.1159/000094154

DO - 10.1159/000094154

M3 - Article

C2 - 16943651

AN - SCOPUS:33748139920

VL - 28

SP - 276

EP - 290

JO - Developmental Neuroscience

JF - Developmental Neuroscience

SN - 0378-5866

IS - 4-5

ER -

Clinical trials in pediatric traumatic brain injury: Unique challenges and potential responses

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this