Clinical trial of desferrioxamine entrapped in red cell ghosts

Ralph Green, J. Lamon, D. Curran

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Ten patients with excess body iron stores of different levels and with different diagnoses were given desferrioxamine inside osmotically lysed and resealed red blood cells (red cell ghosts). Red cell ghost entrapped desferrioxamine was given intravenously and, ten days later, an equal dose of desferrioxamine was adminstered via slow subcutaneous infusion over 10 h. Differences were apparent for these single challenges with respect to the pattern of urine excretion and the efficiency of iron chelation. The red cell ghost method consistently improved the efficiency of chelation, especially in patients with modestly increased body iron stores. This method of treatment may therefore prove to be of particular value in the patient with early siderosis who is embarking on a programme of regular transfusion for refractory anaemia.

Original languageEnglish (US)
Pages (from-to)327-330
Number of pages4
JournalLancet
Volume2
Issue number8190
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Green, R., Lamon, J., & Curran, D. (1980). Clinical trial of desferrioxamine entrapped in red cell ghosts. Lancet, 2(8190), 327-330.