Clinical significance of autoantibodies in dermatomyositis and systemic sclerosis

Danielle Tartar, Lorinda Chung, David F. Fiorentino

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Autoimmune connective tissue diseases, including dermatomyositis and systemic sclerosis, have a heterogeneous clinical presentation and prognosis; moreover, their clinical features are often incomplete and overlap with other rheumatic disorders, which can make diagnosis and prognostic stratification challenging. Specific autoantibodies have been associated with certain clinical findings as well as prognostic implications, and many new associations have been made over the last decade. Although patient populations manifest considerable heterogeneity, autoantibodies can be used to help predict clinical features, prognosis, and response to therapy. In this review, the clinical and prognostic implications associated with disease-specific autoantibodies in dermatomyositis and scleroderma are summarized with an emphasis on how the clinician can use this information for patient care.

Original languageEnglish (US)
Pages (from-to)508-524
Number of pages17
JournalClinics in Dermatology
Issue number4
StatePublished - Jul 1 2018

ASJC Scopus subject areas

  • Dermatology


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