Clinical research strategies for fructose metabolism

Maren R. Laughlin, John P. Bantle, Peter J Havel, Elizabeth Parks, David M. Klurfeld, Karen Teff, Padma Maruvada

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Fructose and simple sugars are a substantial part of the western diet, and their influence on human health remains controversial. Clinical studies in fructose nutrition have proven very difficult to conduct and interpret. NIH and USDA sponsored a workshop on 13-14 November 2012, "Research Strategies for Fructose Metabolism," to identify important scientific questions and parameters to be considered while designing clinical studies. Research is needed to ascertain whether there is an obesogenic role for fructose-containing sugars via effects on eating behavior and energy balance and whether there is a dose threshold beyond which these sugars promote progression toward diabetes and liver and cardiovascular disease, especially in susceptible populations. Studies tend to fall into 2 categories, and design criteria for each are described. Mechanistic studies are meant to validate observations made in animals or to elucidate the pathways of fructose metabolism in humans. These highly controlled studies often compare the pure monosaccharides glucose and fructose. Other studies are focused on clinically significant disease outcomes or health behaviors attributable to amounts of fructose-containing sugars typically found in the American diet. These are designed to test hypotheses generated from short-term mechanistic or epidemiologic studies and provide data for health policy. Discussion brought out the opinion that, although many mechanistic questions concerning the metabolism of monosaccharide sugars in humans remain to be addressed experimentally in small highly controlled studies, health outcomes research meant to inform health policy should use large, longterm studies using combinations of sugars found in the typical American diet rather than pure fructose or glucose.

Original languageEnglish (US)
Pages (from-to)248-259
Number of pages12
JournalAdvances in Nutrition
Volume5
Issue number3
DOIs
StatePublished - 2014

Fingerprint

research planning
Fructose
fructose
metabolism
sugars
Research
health policy
Monosaccharides
monosaccharides
Health Policy
clinical trials
Diet
Glucose
United States Department of Agriculture
glucose
Health Behavior
Health
liver diseases
Feeding Behavior
at-risk population

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Medicine(all)

Cite this

Laughlin, M. R., Bantle, J. P., Havel, P. J., Parks, E., Klurfeld, D. M., Teff, K., & Maruvada, P. (2014). Clinical research strategies for fructose metabolism. Advances in Nutrition, 5(3), 248-259. https://doi.org/10.3945/an.113.005249

Clinical research strategies for fructose metabolism. / Laughlin, Maren R.; Bantle, John P.; Havel, Peter J; Parks, Elizabeth; Klurfeld, David M.; Teff, Karen; Maruvada, Padma.

In: Advances in Nutrition, Vol. 5, No. 3, 2014, p. 248-259.

Research output: Contribution to journalArticle

Laughlin, MR, Bantle, JP, Havel, PJ, Parks, E, Klurfeld, DM, Teff, K & Maruvada, P 2014, 'Clinical research strategies for fructose metabolism', Advances in Nutrition, vol. 5, no. 3, pp. 248-259. https://doi.org/10.3945/an.113.005249
Laughlin MR, Bantle JP, Havel PJ, Parks E, Klurfeld DM, Teff K et al. Clinical research strategies for fructose metabolism. Advances in Nutrition. 2014;5(3):248-259. https://doi.org/10.3945/an.113.005249
Laughlin, Maren R. ; Bantle, John P. ; Havel, Peter J ; Parks, Elizabeth ; Klurfeld, David M. ; Teff, Karen ; Maruvada, Padma. / Clinical research strategies for fructose metabolism. In: Advances in Nutrition. 2014 ; Vol. 5, No. 3. pp. 248-259.
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