Clinical presentation, treatment and outcome in 31 dogs with presumed primary colorectal lymphoma (2001-2013)

I. Desmas, Jenna H Burton, G. Post, O. Kristal, M. Gauthier, J. F. Borrego, A. Di Bella, A. Lara-Garcia

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The objective of this multicentre retrospective study was to describe clinical presentation, treatment and outcome and to determine prognostic factors for dogs with presumed primary colorectal lymphoma (PCRL). A total of 31 dogs were included. The predominant features of PCRL were high grade (n=18) and immunophenotype B (n=24). Most dogs were substage b (n=25) with higher prevalence of haematochezia (n=20). One dog had surgery only. Thirty dogs received chemotherapy; amongst them 13 had surgery or radiotherapy. Progression free survival (PFS) was 1318days and disease-related median survival time (MST) was 1845days. Fourteen dogs were alive at the end of the study with a median follow-up time of 684days (3-4678days). Younger dogs had longer PFS (P=0.031) and disease-related MST (P=0.01). Presence of haematochezia corresponded with longer PFS (P=0.02). Addition of local treatment to chemotherapy did not significantly improve the outcome (P=0.584). Canine PCRL has considerably longer PFS and MST than other forms of non-Hodgkin's lymphoma.

Original languageEnglish (US)
JournalVeterinary and Comparative Oncology
DOIs
StateAccepted/In press - 2016
Externally publishedYes

Keywords

  • Canine
  • Chemotherapy
  • Colorectal
  • Lymphoma

ASJC Scopus subject areas

  • veterinary(all)

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