Clinical presentation, diagnostic findings, and outcome of adult horses with equine coronavirus infection at a veterinary teaching hospital

33 cases (2012–2018)

E. H. Berryhill, K. G. Magdesia, Monica R Aleman, Nicola Pusterla

Research output: Contribution to journalArticle

Abstract

Equine coronavirus (ECoV)is a recently described enteric virus with worldwide outbreaks; however, there are little data available on clinical presentation, diagnosis, and outcome. The study objective was to document case management of ECoV in adult horses presented to a referral hospital and compare to a cohort of horses that tested negative for ECoV. A retrospective case series was performed based on positive real-time quantitative PCR results for ECoV on faeces from horses treated at the UC Davis Veterinary Medical Teaching Hospital from 1 March 2012 to 31 March 2018. Horses negative for ECoV were matched to the ECoV-positive group as controls. Data collected included signalment, history, exam findings, diagnostics, treatment, and follow-up. Thirty-three horses (median age, 11 years; range, 2–37 years)tested ECoV-positive, including three horses with co-infections. Presenting complaints for ECoV-infected horses included historic fevers (n = 25/30; 83%), anorexia (n = 14/30; 47%), and colic (n = 13/30; 43%). ECoV-positive horses had significantly lower white blood cell (median, 3.0 × 10 9 /L; range, 0.68–16.2 × 10 9 /L), neutrophil (median, 1.26 × 10 9 /L; range, 0.15–14.4 × 10 9 /L), and lymphocyte (median, 0.86 × 10 9 /L; range, 0.42–3.47 × 10 9 /L)counts than ECoV-negative horses. Electrolyte and metabolic derangements and scant faeces were common. Twenty-seven horses were hospitalised for a median of 5 days (range, 0.5–14 days), with 26/27 (96%)horses surviving to discharge. ECoV infection should be a differential diagnosis for adult horses with fever, colic, anorexia, and leukopenia. The disease has a low mortality rate, but horses may require intensive care to resolve severe leukopenia, systemic inflammation, and metabolic disturbances.

Original languageEnglish (US)
Pages (from-to)95-100
Number of pages6
JournalVeterinary Journal
Volume248
DOIs
StatePublished - Jun 1 2019

Fingerprint

Coronavirus Infections
Animal Hospitals
Coronavirinae
Teaching Hospitals
Horses
horses
Coronavirus
infection
leukopenia
Colic
colic
Leukopenia
Anorexia
anorexia
Feces
fever

Keywords

  • Colic
  • Diarrhea
  • Fever
  • Gastrointestinal
  • Infectious

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

@article{04c30c038c084853a281ada388728d48,
title = "Clinical presentation, diagnostic findings, and outcome of adult horses with equine coronavirus infection at a veterinary teaching hospital: 33 cases (2012–2018)",
abstract = "Equine coronavirus (ECoV)is a recently described enteric virus with worldwide outbreaks; however, there are little data available on clinical presentation, diagnosis, and outcome. The study objective was to document case management of ECoV in adult horses presented to a referral hospital and compare to a cohort of horses that tested negative for ECoV. A retrospective case series was performed based on positive real-time quantitative PCR results for ECoV on faeces from horses treated at the UC Davis Veterinary Medical Teaching Hospital from 1 March 2012 to 31 March 2018. Horses negative for ECoV were matched to the ECoV-positive group as controls. Data collected included signalment, history, exam findings, diagnostics, treatment, and follow-up. Thirty-three horses (median age, 11 years; range, 2–37 years)tested ECoV-positive, including three horses with co-infections. Presenting complaints for ECoV-infected horses included historic fevers (n = 25/30; 83{\%}), anorexia (n = 14/30; 47{\%}), and colic (n = 13/30; 43{\%}). ECoV-positive horses had significantly lower white blood cell (median, 3.0 × 10 9 /L; range, 0.68–16.2 × 10 9 /L), neutrophil (median, 1.26 × 10 9 /L; range, 0.15–14.4 × 10 9 /L), and lymphocyte (median, 0.86 × 10 9 /L; range, 0.42–3.47 × 10 9 /L)counts than ECoV-negative horses. Electrolyte and metabolic derangements and scant faeces were common. Twenty-seven horses were hospitalised for a median of 5 days (range, 0.5–14 days), with 26/27 (96{\%})horses surviving to discharge. ECoV infection should be a differential diagnosis for adult horses with fever, colic, anorexia, and leukopenia. The disease has a low mortality rate, but horses may require intensive care to resolve severe leukopenia, systemic inflammation, and metabolic disturbances.",
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