Clinical predictors of endometritis in women with symptoms and signs of pelvic inflammatory disease

Jeffrey F. Peipert, Roberta B. Ness, Jeffrey Blume, David E. Soper, Robert Holley, Hugh Randall, Richard L Sweet, Steven J. Sondheimer, Susan L. Hendrix, Antonio Amortegui, Giuliana Trucco, Debra C. Bass

Research output: Contribution to journalArticlepeer-review

99 Scopus citations


OBJECTIVE: Careful detection and treatment of pelvic inflammatory disease are essential for the prevention of adverse sequelae. The purpose of this study was to evaluate the diagnostic test characteristics of clinical criteria for the diagnosis of pelvic inflammatory disease. STUDY DESIGN: We performed a cross-sectional analysis of the baseline characteristics of 651 patients enrolled in a multicenter randomized treatment trial for pelvic inflammatory disease. Clinical and laboratory findings were recorded for all patients, and endometrial sampling was performed. We calculated sensitivity and specificity and performed receiver operating characteristic curve analysis and multivariate logistic regression, using histologic endometritis as the criterion standard. RESULTS: The minimal criteria for pelvic inflammatory disease, as recommended by the Centers for Disease Control and Prevention, had a sensitivity of 83%, in comparison with a 95% sensitivity for adnexal tenderness (P = .001). Of the supportive clinical criteria, the finding most highly associated with endometritis was a positive test result for Chlamydia trachomatis or Neisseria gonorrhoeae (adjusted odds ratio, 4.3; 95% confidence interval, 2.89-6.63). A multivariate logistic regression model indicated that combinations of criteria significantly improve the prediction of endometritis. CONCLUSION: Sensitivity can be maximized by using the presence of adnexal tenderness as a minimal criterion for the diagnosis of pelvic inflammatory disease, and supportive criteria are helpful in estimating the probability of endometritis.

Original languageEnglish (US)
Pages (from-to)856-864
Number of pages9
JournalAmerican Journal of Obstetrics and Gynecology
Issue number5
StatePublished - 2001
Externally publishedYes


  • Adnexitis
  • Diagnosis
  • Endometritis
  • Pelvic inflammatory disease
  • Salpingitis

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology


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