Clinical pharmacokinetics of drugs used in the treatment of breast cancer

V. J. Wiebe, C. C. Benz, M. W. DeGregorio

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

This article reviews the absorption, bioavailability, distribution, metabolism, and elimination patterns of the agents most commonly used for the treatment of breast cancer. Although the majority of the pharmacokinetic studies reviewed have been examined in non-breast cancer patients, the kinetic findings are not significantly altered by disease state. The anthracyclines, antimetabolites, alkylating agents, antioestrogens and mitotic inhibitors are among the classes of agents used to treat breast cancer. Although extensively examined, cancer pharmacokinetic research has resulted in very few clinically relevant findings in breast cancer.

Original languageEnglish (US)
Pages (from-to)180-193
Number of pages14
JournalClinical Pharmacokinetics
Volume15
Issue number3
StatePublished - 1988

Fingerprint

Pharmacokinetics
Breast Neoplasms
Pharmaceutical Preparations
Antimetabolites
Estrogen Receptor Modulators
Alkylating Agents
Anthracyclines
Biological Availability
Neoplasms
Therapeutics
Research

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Wiebe, V. J., Benz, C. C., & DeGregorio, M. W. (1988). Clinical pharmacokinetics of drugs used in the treatment of breast cancer. Clinical Pharmacokinetics, 15(3), 180-193.

Clinical pharmacokinetics of drugs used in the treatment of breast cancer. / Wiebe, V. J.; Benz, C. C.; DeGregorio, M. W.

In: Clinical Pharmacokinetics, Vol. 15, No. 3, 1988, p. 180-193.

Research output: Contribution to journalArticle

Wiebe, VJ, Benz, CC & DeGregorio, MW 1988, 'Clinical pharmacokinetics of drugs used in the treatment of breast cancer', Clinical Pharmacokinetics, vol. 15, no. 3, pp. 180-193.
Wiebe, V. J. ; Benz, C. C. ; DeGregorio, M. W. / Clinical pharmacokinetics of drugs used in the treatment of breast cancer. In: Clinical Pharmacokinetics. 1988 ; Vol. 15, No. 3. pp. 180-193.
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