Clinical PET with a large area multiwire proportional chamber PET camera

R. J. Ott, P. K. Marsden, M. A. Flower, S. Webb, Simon R Cherry, V. R. McCready, J. E. Bateman

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

A large-area multiwire proportional chamber positron camera (MUP-PET) is under evaluation for clinical nuclear medicine use remote from a medical cyclotron. A preliminary physical evaluation shows that the detector has a sensitivity 5-10 times that of a conventional gamma camera but one tenth that of a multicrystal, multiring PET system. The spatial resolution is 6 mm throughout an imaging volume 40 cm diameter by 20 cm axially. The electronic readout presently limits the data acquisition rates to ∼ 2-3 kcps. The system has potential to acquire data at 50 kcps with a further increase in sensitivity of 5-10 and an improved resolution of 3 mm. The camera is under evaluation for clinical use in oncological studies using radiopharmaceuticals labelled with 68Ga from an in-house generator plus longer-lived radionuclides (18F, 124I, 55Co, 68Ga) from off-site cyclotrons. In particular quantitative measurements of dosimetry in both chemotherapy and radiotherapy will be an important part of the work.

Original languageEnglish (US)
Pages (from-to)436-442
Number of pages7
JournalNuclear Inst. and Methods in Physics Research, A
Volume269
Issue number2
DOIs
StatePublished - Jun 10 1988
Externally publishedYes

ASJC Scopus subject areas

  • Instrumentation
  • Nuclear and High Energy Physics
  • Engineering(all)

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