Clinical outcomes, ultrastructure and immunohistochemical features of canine high-grade olfactory neuroblastoma

Molly E. Church, Sridhar M. Veluvolu, Amy C. Durham, Kevin D Woolard

Research output: Contribution to journalArticle

Abstract

Olfactory neuroblastoma (ONB) is a rare intranasal neoplasm in both dogs and humans. Similar clinical presentation and overlapping histologic and immunohistochemical features of ONB with other intranasal neoplasms can make diagnosis and treatment of intranasal neoplasia challenging. Furthermore, in part because of their rarity, there is a lack of reporting on therapeutic regimen for these neoplasms. In humans, initial debulking surgery is usually followed by radiation therapy. Here we report on the histologic, immunohistochemical, and ultrastructural characteristics of canine ONB and report on the clinical progression of cases treated with radiation therapy. In all nine canine ONB examined here, neoplastic cells were arranged in a lobular manner amidst a prominent neurofibrillary matrix and had features consistent with Grade III (high grade) ONB. The neoplastic cells demonstrated positive immunohistochemical staining for TuJ-1, a Class III beta-tubulin neuronal cytoskeletal protein, and variable staining for other markers, including chromogranin, synaptophysin, AE1/AE3 and MAP2. The longest surviving case was treated with a regimen similar to that used in humans, consisting of debulking surgery followed by definitive radiation therapy. Our study found that TuJ-1 is a useful marker for ONB and that radiation therapy, even in cases of advanced disease, may result in prolonged survival.

Original languageEnglish (US)
JournalVeterinary and Comparative Oncology
DOIs
StatePublished - Jan 1 2019

Fingerprint

Olfactory Esthesioneuroblastoma
radiotherapy
Canidae
ultrastructure
neoplasms
dogs
Radiotherapy
surgery
cytoskeletal proteins
Neoplasms
tubulin
Staining and Labeling
Chromogranins
Synaptophysin
Cytoskeletal Proteins
Tubulin
therapeutics
Dogs
Survival
Therapeutics

Keywords

  • canine nasal tumours
  • esthesioneuroblastoma
  • olfactory neuroblastoma
  • radiotherapy
  • TuJ-1

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Clinical outcomes, ultrastructure and immunohistochemical features of canine high-grade olfactory neuroblastoma. / Church, Molly E.; Veluvolu, Sridhar M.; Durham, Amy C.; Woolard, Kevin D.

In: Veterinary and Comparative Oncology, 01.01.2019.

Research output: Contribution to journalArticle

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