Clinical nuclear magnetic resonance spectroscopy

Insight into metabolism

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Nuclear magnetic resonance (NMR) spectroscopy can nondestructively evaluate changes in metabolites with different disease states, as well as with therapeutic interventions. Animal studies have provided the basis for understanding changes in high-energy phosphates with myocardial ischemia. Studies of graded ischemia due to partial coronary stenosis have shown the sensitivity of the ratio of phosphocreatinine to inorganic phosphate to small reductions in myocardial blood flow and its relation to myocardial function. The application of NMR spectroscopy to humans requires precise localization techniques to avoid acquiring contaminating information from structures around the heart, such as the chest wall and diaphragm. With these localization techniques, metabolic evidence of ischemia has been demonstrated in patients with myocardial infarction and patients with known coronary disease, although the sensitivity of this technique for the diagnosis of inducible ischemia is unknown. At rest, patients with dilated and hypertrophic cardiomyopathies often have an elevated phosphodiester resonance, possibly signifying abnormal breakdown of membrane phospholipids. Increasing oxygen demand in these patients does not usually alter high-energy phosphates, suggesting that oxidative energy metabolism is preserved under these conditions. NMR spectroscopy is a powerful tool to increase understanding of metabolic changes in a variety of pathologic conditions.

Original languageEnglish (US)
JournalThe American journal of cardiology
Volume66
Issue number14
DOIs
StatePublished - Oct 26 1990

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Magnetic Resonance Spectroscopy
Ischemia
Phosphates
Coronary Stenosis
Hypertrophic Cardiomyopathy
Dilated Cardiomyopathy
Thoracic Wall
Diaphragm
Energy Metabolism
Myocardial Ischemia
Coronary Disease
Phospholipids
Myocardial Infarction
Oxygen
Membranes
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Clinical nuclear magnetic resonance spectroscopy : Insight into metabolism. / Schaefer, Saul.

In: The American journal of cardiology, Vol. 66, No. 14, 26.10.1990.

Research output: Contribution to journalArticle

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