Clinical, morphological and immunohistochemical characterization of cutaneous lymphocytosis in 23 cats

S. Gilbert, V. K. Affolter, T. L. Gross, P. F. Moore, P. J. Ihrke

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26 Scopus citations


Clinical, morphological and immunohistochemical features of cutaneous lymphocytosis, an uncommon disease histologically resembling well-differentiated malignant lymphoma, were characterized in 23 cats. Clinical outcome was correlated with histomorphology and immunophenotype in an attempt to predict benign vs. malignant behaviour. The disease mainly affected older cats. Lesions were solitary in 61% of cats and often characterized by alopecia (73.9%), as well as erythema, scaling and ulceration. The lateral thorax was most commonly affected (43.5%). Pruritus was frequent (65.2%). Systemic signs included anorexia and weight loss. Morphologically, lesions were characterized by dermal infiltrations of well-differentiated CD3+ T-cells (100%) and aggregates of CD79+ B-cells (64.3%). Cutaneous lymphocytosis is slowly progressive and relatively benign, although in some cats systemic signs led to euthanasia. Four of 12 euthanized cats and one live cat also had lymphoid infiltrates in internal organs. Unfortunately, we were unable to predict clinical outcome by histological and immunohistochemical evaluations of skin lesions.

Original languageEnglish (US)
Pages (from-to)3-12
Number of pages10
JournalVeterinary Dermatology
Issue number1
StatePublished - Feb 2004
Externally publishedYes


  • Alopecia
  • Cat
  • Cutaneous lymphocytosis
  • Cutaneous lymphoma
  • Lymphocytes
  • Pseudolymphoma
  • T-cells

ASJC Scopus subject areas

  • veterinary(all)


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