Clinical, microscopic, and molecular aspects of canine leproid granuloma in the United States.

Janet E Foley, Dori L Borjesson, T. L. Gross, C. Rand, M. Needham, A. Poland

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Leproid granulomas from seven dogs in the United States were evaluated. Gross characteristics included nodular and ulcerated dermal and subcutaneous lesions primarily on the caudal aspects of the pinnae and to a lesser extent on the muzzle, face, and forelimbs. In all except one dog, there was complete regression of the lesions within 6 months, either with no therapy or after surgical resection. Cytology or histopathology revealed pyogranulomatous inflammation with few to many acid-fast mycobacterial bacilli within macrophages. The organisms could not be cultivated in vitro. DNA sequencing of part of the 16S ribosomal RNA gene region revealed 99-100% homology among fragments from five of these dogs and fragments from dogs in the south Pacific. This syndrome occurs in dogs in North America and the prognosis is excellent, in contrast to the prognosis for rapid-growing or tuberculous mycobacteriosis.

Original languageEnglish (US)
Pages (from-to)234-239
Number of pages6
JournalVeterinary Pathology
Volume39
Issue number2
StatePublished - Mar 2002

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granuloma
Granuloma
Canidae
Dogs
dogs
lesions (animal)
prognosis
16S Ribosomal RNA
mycobacterial diseases
Forelimb
resection
North America
forelimbs
DNA Sequence Analysis
rRNA Genes
cell biology
histopathology
Bacillus
Cell Biology
macrophages

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Clinical, microscopic, and molecular aspects of canine leproid granuloma in the United States. / Foley, Janet E; Borjesson, Dori L; Gross, T. L.; Rand, C.; Needham, M.; Poland, A.

In: Veterinary Pathology, Vol. 39, No. 2, 03.2002, p. 234-239.

Research output: Contribution to journalArticle

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