Clinical implications of neuroendocrine differentiation in prostate cancer

E. C. Nelson, A. J. Cambio, J. C. Yang, J. H. Ok, Primo N Lara, Christopher P Evans

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The cellular signaling pathways of the prostate play a central role in the induction, maintenance, and progression of prostate cancer (CaP). Neuroendocrine (NE) cells demonstrate attributes that suggest they are an integral part of these signaling cascades. We summarize what is known regarding NE cells in CaP focusing on NE cellular transdifferentiation. This significant event in CaP progression appears to be accelerated by androgen deprivation (AD) treatment. We examine biochemical pathways that may impact NE differentiation in a chronological manner focusing on AD therapy (ADT) as a central event in inducing androgen-independent CaP. Our analysis is limited to the common adenocarcinoma pattern of CaP and excludes small-cell and carcinoid prostatic variants. In conclusion, we speculate on the future of treatment and research in this area.

Original languageEnglish (US)
Pages (from-to)6-14
Number of pages9
JournalProstate Cancer and Prostatic Diseases
Volume10
Issue number1
DOIs
StatePublished - Mar 2007

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Androgens
Neuroendocrine Cells
Prostatic Neoplasms
Carcinoid Tumor
Prostate
Adenocarcinoma
Maintenance
Research
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Clinical implications of neuroendocrine differentiation in prostate cancer. / Nelson, E. C.; Cambio, A. J.; Yang, J. C.; Ok, J. H.; Lara, Primo N; Evans, Christopher P.

In: Prostate Cancer and Prostatic Diseases, Vol. 10, No. 1, 03.2007, p. 6-14.

Research output: Contribution to journalArticle

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